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首页> 外文期刊>Preventive Medicine: An International Journal Devoted to Practice and Theory >Cumulative exposure to particulate matter air pollution and long-term post-myocardial infarction outcomes
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Cumulative exposure to particulate matter air pollution and long-term post-myocardial infarction outcomes

机译：累积暴露于颗粒物空气污染和长期心肌梗塞后预后

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Introduction: Chronic environmental exposure to particulate matter 2.5μm in diameter (PM2.5) has been associated with cardiovascular disease; however, the effect of air pollution on myocardial infarction (MI) survivors is not clear. We studied the association of chronic exposure to PM2.5 with death and recurrent cardiovascular events in MI survivors. Methods: Consecutive patients aged ≤65years admitted to all medical centers in central Israel after first-MI in 1992-1993 were followed through 2005 for cardiovascular events and 2011 for survival. Data on sociodemographic and prognostic factors were collected at baseline and during follow-up. Residential exposure to PM2.5 was estimated for each patient based on data recorded at air quality monitoring stations. Cox and Andersen-Gill proportional hazards models were used to study the pollution-outcome association. Results: Among the 1120 patients, 469 (41.9%) died and 541 (48.3%) experienced one or more recurrent cardiovascular event. The adjusted hazard ratios associated with a 10μg/m3 increase in PM2.5 exposure were 1.3 (95% CI 0.8-2.1) for death and 1.5 (95% CI 1.1-1.9) for multiple recurrences of cardiovascular events (MI, heart failure and stroke). Conclusion: When adjustment for socio-demographic factors is performed, cumulative chronic exposure to PM2.5 is positively associated with recurrence of cardiovascular events in patients after a first MI.
机译：简介：慢性环境暴露于直径小于2.5μm的颗粒物（PM2.5）与心血管疾病有关;然而，空气污染对心肌梗死幸存者的影响尚不清楚。我们研究了MI幸存者中长期暴露于PM2.5与死亡和心血管事件复发之间的关系。方法：1992年至1993年首次MI后进入以色列中部所有医疗中心的≤65岁连续患者，随访至2005年的心血管事件和2011年的生存期。在基线和随访期间收集了社会人口统计学和预后因素的数据。根据空气质量监测站记录的数据，估计每位患者的住宅暴露于PM2.5。使用Cox和Andersen-Gill比例风险模型研究污染结果关联。结果：在1120例患者中，有469例（41.9％）死亡，541例（48.3％）经历了一次或多次复发性心血管事件。与PM2.5暴露量增加10μg/ m3有关的调整后的危险比是死亡（1.3）（95％CI 0.8-2.1）和心血管疾病（MI，心力衰竭和心律失常）多次复发1.5（95％CI 1.1-1.9）。中风）。结论：在进行社会人口统计学因素调整后，首次MI后患者长期累积暴露于PM2.5与心血管事件的复发呈正相关。

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