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首页> 外文期刊>Preventive Medicine: An International Journal Devoted to Practice and Theory >Premenopausal risk factors for coronary and aortic calcification: a 20-year follow-up in the healthy women study.
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Premenopausal risk factors for coronary and aortic calcification: a 20-year follow-up in the healthy women study.

机译：绝经前冠状动脉和主动脉钙化的危险因素：健康女性研究的20年随访。

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OBJECTIVE: It is important to understand the early development of subclinical cardiovascular disease (CVD) in women to prevent costly morbidity and mortality associated with CVD events. METHODS: 363 Women enrolled in the Healthy Women Study, Allegheny County, PA, had electron beam tomography measures of coronary (CaC) and aortic (AC) calcification on average 14.6 years after study entry in 1983; 267 had a second EBT 6.4 years later, by 2006. Risk factors were assessed when women were premenopausal and 5 years after the menopause. RESULTS: Step-wise logistic regression analyses showed that the independent premenopausal predictors of CaC > or = 100 14.6 years later were low-density lipoprotein cholesterol, OR=1.15 (1.03-1.29 for 10 mg/dl) and current smoker, OR=2.72, 1.29-5.71. The same premenopausal risk factors were predictors of AC > or = 500, in addition to premenopausal systolic blood pressure (SBP). Similar results were obtained for predicting calcification 20.6 years later. Postmenopausal risk factors measured 5 years prior to the initial scans were unrelated to CaC and AC, after the significant premenopausal risk factors were taken into account, except for postmenopausal SBP being related to AC. CONCLUSION: Premenopausal risk factors are strong predictors of postmenopausal CaC and AC. Clinical trials should test if reduction of premenopausal levels of risk factors reduces the risk of early calcification.
机译：目的：重要的是要了解女性亚临床心血管疾病（CVD）的早期发展，以防止与CVD事件相关的代价高昂的发病率和死亡率。方法：参加宾夕法尼亚州阿勒格尼县健康妇女研究的363名妇女在1983年进入研究后平均14.6年进行了电子束断层扫描，测量的是冠状动脉（CaC）和主动脉（AC）钙化; 267人在6.4年后（即2006年）接受了第二次EBT。评估了妇女绝经前和绝经5年后的危险因素。结果：逐步logistic回归分析显示，CaC>或= 100 14.6年后，绝经前的独立预测因子为低密度脂蛋白胆固醇，OR = 1.15（10 mg / dl为1.03-1.29）和当前吸烟者，OR = 2.72 ，1.29-5.71。除绝经前收缩压（SBP）以外，绝经前相同的危险因素也是AC>或= 500的预测因子。 20.6年后，获得了类似的预测钙化的结果。在考虑了绝经前的重大危险因素后，首次扫描前5年测得的绝经后危险因素与CaC和AC无关，但绝经后SBP与AC有关。结论：绝经前危险因素是绝经后CaC和AC的强烈预测指标。临床试验应测试绝经前危险因素水平的降低是否会降低早期钙化的风险。

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