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首页> 外文期刊>Preventive Medicine: An International Journal Devoted to Practice and Theory >STrengthening the Reporting of OBservational studies in Epidemiology - Molecular Epidemiology (STROBE-ME): an extension of the STROBE statement.
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STrengthening the Reporting of OBservational studies in Epidemiology - Molecular Epidemiology (STROBE-ME): an extension of the STROBE statement.

机译：加强流行病学观察研究的报告-分子流行病学（STROBE-ME）：对STROBE声明的扩展。

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摘要

Advances in laboratory techniques have led to a rapidly increasing use of biomarkers in epidemiological studies. Biomarkers of internal dose, early biological change, susceptibility and clinical outcomes are used as proxies for investigating the interactions between external and/or endogenous agents and the body components or processes. The need for improved reporting of scientific research led to influential statements of recommendations such as the STrenghtening Reporting of Observational studies in Epidemiology (STROBE) statement. The STROBE initiative established in 2004 aimed to provide guidance on how to report observational research. Its guidelines provide a user-friendly checklist of 22 items to be reported in epidemiological studies, with items specific to the three main study designs: cohort studies, case-control studies and cross-sectional studies. The present STrengthening the Reporting of OBservational studies in Epidemiology - Molecular Epidemiology (STROBE-ME) initiative builds on the STROBE Statement implementing 9 existing items of STROBE and providing 17 additional items to the 22 items of STROBE checklist. The additions relate to the use of biomarkers in epidemiological studies, concerning collection, handling and storage of biological samples; laboratory methods, validity and reliability of biomarkers; specificities of study design; and ethical considerations. The STROBE-ME recommendations are intended to complement the STROBE recommendations.
机译：实验室技术的进步导致在流行病学研究中生物标记物的使用迅速增加。内部剂量，早期生物学变化，药敏性和临床结果的生物标志物被用作研究外部和/或内源性药物与身体成分或过程之间相互作用的代理。由于需要改进科学研究报告，因此产生了有影响力的建议，例如流行病学观察性研究的加强报告（STROBE）。 2004年建立的STROBE计划旨在为如何报告观测研究提供指导。它的指南为流行病学研究中要报告的22个项目提供了用户友好的清单，其中包含针对以下三个主要研究设计的特定项目：队列研究，病例对照研究和横断面研究。当前的《流行病学观察研究报告-分子流行病学》（STROBE-ME）计划建立在STROBE声明的基础上，该声明实施了9个STROBE现有项目，并为22个STROBE清单提供了17个其他项目。增加的内容涉及在流行病学研究中使用生物标志物，涉及生物样品的收集，处理和储存;实验室方法，生物标志物的有效性和可靠性;研究设计的特殊性;和道德考量。 STROBE-ME建议旨在补充STROBE建议。

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