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首页> 外文期刊>Preventive Medicine: An International Journal Devoted to Practice and Theory >Towards more eclectic evidence-based medicine in cancer prevention and control
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Towards more eclectic evidence-based medicine in cancer prevention and control

机译：在癌症预防和控制方面寻求更加折衷的循证医学

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Much has been said about the limits of observational studies in providing an unequivocal body of evidence to identify causes of disease and the premises for preventive strategies (Taubes, 1995). The unpalatable lessons from the beta-carotene and lung cancer association among smokers (Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group, 1994; Omenn et al, 1996), as well as others of more recent aftertaste, such as hormone replacement therapy and heart disease (Rossouw et al., 2002), are now part of any anthology of preventive medicine. Medical students learn that randomized controlled trials (RCTs), whenever feasible and ethically tenable, provide the highest grade of evidence for or against a new health intervention. Healthcare providers, particularly in litigation-prone settings, adhere strictly to professional guidelines that rely primarily or nearly exclusively on RCT-based evidence for specific diagnostic tests or therapies. Likewise, in an era of rapidly evolving technologies competing for diminishing budgets, policymakers are just as evangelical of the high bar of RCT-based health technology assessment.
机译：关于观察性研究的局限性，在提供明确的证据以查明疾病原因和预防策略的前提方面，已经有很多说法（Taubes，1995）。吸烟者从β-胡萝卜素和肺癌的关联中学到了令人不快的教训（Alpha-生育酚，Beta胡萝卜素癌症预防研究小组，1994年; Omenn等人，1996年），以及其他较新的回味剂，例如激素替代疗法和心脏病（Rossouw等，2002）现在已成为任何预防医学选集的一部分。医学生了解到，随机对照试验（RCT）在可行且符合伦理原则的情况下，可以为新的健康干预措施提供有力的证据。医疗保健提供者（尤其是在容易诉讼的环境中）严格遵守专业准则，该准则主要或几乎完全依赖基于RCT的证据进行特定的诊断测试或疗法。同样，在一个技术日新月异，预算不断减少的时代，政策制定者对基于RCT的健康技术评估的崇高标准也是如此。

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