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首页> 外文期刊>Preventive Medicine: An International Journal Devoted to Practice and Theory >Insight into the causes of the recent secular trend in pediatric obesity: Common sense does not always prevail for complex, multi-factorial phenotypes.
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Insight into the causes of the recent secular trend in pediatric obesity: Common sense does not always prevail for complex, multi-factorial phenotypes.

机译：了解近期儿童肥胖的长期趋势的成因：复杂的多因素表型并非总是常识。

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摘要

Although the secular increase in pediatric obesity is well-documented, there has been no serious attempt to systematically address the causes of this secular trend. The aim of this paper is to provide a better understanding of the possible causes of the recent secular increase in pediatric obesity by reviewing and synthesizing the available literature pertaining to the topic. The paper addresses caveats and important considerations regarding the body mass index, physical activity, and diet and also considers alternative explanations (stress, sleep, maternal health, epigenetic mechanisms) for the secular trend. It is likely that the increased BMI is due to both an increased fat-free mass and fat mass (including waist circumference). Although total caloric intake has remained unchanged, there was a clear trend in increased simple sugar consumption. It is conceivable that total energy expenditure has decreased because of a decline in spontaneous but not voluntary physical activity. Several indicators of psycho-social stress (antidepressant medication prescriptions and suicide attempts, anxiety) have increased along with a decreased sleep duration. Finally, there is intriguing evidence that suggests that the secular trend is related to a common origin in fetal life that is exacerbated by postnatal events/stressors. The insight gained from examining the possible causes of the trend provides a better understanding of the basic etiology of pediatric obesity and should be incorporated into prevention and intervention models.
机译：尽管小儿肥胖症的长期增加已得到充分证明，但仍未进行认真的尝试来系统地解决这种长期趋势的原因。本文的目的是通过回顾和综合与该主题有关的现有文献，更好地了解近期小儿肥胖的长期增长的可能原因。本文讨论了有关体重指数，体育锻炼和饮食的注意事项和重要考虑因素，还考虑了长期趋势的其他解释（压力，睡眠，孕产妇健康，表观遗传机制）。 BMI升高可能是由于无脂肪量和脂肪量（包括腰围）增加所致。尽管总热量摄入保持不变，但单糖消耗量有明显的增加趋势。可以想象，由于自发的但不是自愿的体育活动减少，总的能量消耗减少了。心理社会压力的几个指标（抗抑郁药物处方和自杀未遂，焦虑）随着睡眠时间的减少而增加。最后，有有趣的证据表明，世俗趋势与胎儿生活中的共同起源有关，而胎儿后世的事件/压力加剧了这一普遍趋势。通过检查趋势的可能原因获得的见解可更好地了解小儿肥胖的基本病因，应将其纳入预防和干预模型。

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