...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Preventive Medicine: An International Journal Devoted to Practice and Theory >Late influenza vaccination is associated with reduced effectiveness.
【24h】

Late influenza vaccination is associated with reduced effectiveness.

机译：晚期流感疫苗接种与有效性降低有关。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Extensive research has been carried out to quantify the efficacy and immunologic responses to influenza immunization, however, only little was reported on whether the timing of vaccine administration affects its effectiveness. The study aims were to compare post-immunization hospitalization and mortality rates among high-risk patients who were vaccinated against influenza in different periods of autumn. METHODS: Data for the current population-based historical prospective study were obtained from a large health organization in Israel insuring 1,600,000 members. Study population (n = 68,166) included high-risk patients aged 55 and above, who were immunized against influenza between October and November 2003. RESULTS: Although at baseline, individuals vaccinated in late November (12-25/11/2003) were significantly younger and had lower burden of illness compared to those vaccinated in early October (1-13/10/2003), they had higher hospitalization rates and longer hospital stay during the following winter (December to March). They also had an increased risk for all-cause mortality (RR = 1.78; 95%CI: 1.13-2.80). No such differences were observed during the following summer (April-August). CONCLUSIONS: In countries where influenza generally peaks between December and early March, vaccines administered after mid-November might be less beneficial.
机译：背景：已经进行了广泛的研究以量化对流感免疫的功效和免疫反应，但是，关于疫苗接种时间是否影响其有效性的报道很少。该研究的目的是比较在秋季不同时期接种流感疫苗的高危患者的免疫后住院率和死亡率。方法：当前基于人口的历史前瞻性研究的数据是从以色列一个大型卫生组织获得的，该组织为1,600,000名成员提供了保险。研究人群（n = 68,166）包括55岁及以上的高危患者，他们在2003年10月至11月之间接受了流感疫苗免疫。结果：尽管在基线时，在11月下旬（2003年12月15日至11月11日）接种疫苗的人群明显与10月初（2003年1月13日）接种疫苗的人相比，他们年龄较小，患病率较低，在接下来的冬季（12月至3月），他们的住院率更高，住院时间更长。他们的全因死亡率风险也增加了（RR = 1.78; 95％CI：1.13-2.80）。在接下来的夏天（4月至8月）没有观察到这种差异。结论：在流感一般在12月至3月上旬达到高峰的国家中，11月中旬以后施用的疫苗可能不利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号