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首页> 外文期刊>Preventive Medicine: An International Journal Devoted to Practice and Theory >Cancers, mainly male, as population biomarkers for breast cancer mortality.
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Cancers, mainly male, as population biomarkers for breast cancer mortality.

机译：癌症，主要是男性，作为乳腺癌死亡率的人群生物标志物。

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BACKGROUND: BCM correlates significantly with mor tality from other site-specific cancers and cardiovascular diseases for both sexes. These other mortalities could be used as independent biomarkers (predictors) of BCM allowing an evaluation of the importance of common etiological factors. METHODS: BCM (age-adjusted, 45-74 years), obtained around 1992 from 37 countries worldwide, was estimated in multivariate regression to identify the best predictors. RESULTS: Male and female biomarkers predicted BCM with a R(2) of 0.80 and 0. 69, respectively. Strongest correlation was obtained with male colon, prostate, lung, and rectum cancer and female esophagus cancer (R(2) = 0.84, P < 0.0001). The estimated independent mean percentage contribution +/- SD to BCM was 40 +/- 7 from prostate cancer, 38 +/- 9 from male colon, 13 +/- 6 from male lung and rectum cancer combined, and 9 +/- 3 from female esophagus cancer. The regression equation (1992 data) predicted mean BCM in 28 available countries from 1967 to 1991 with a mean error of 5%. BCM in individual countries was also reliably predicted from 1967 to 1991, r = 0.86 to 0.90 (P < 0.0001). In 1953, r was 0.74 (P < 0.0001). CONCLUSIONS: The evidence suggests a major influence of modifiable environmental factors common to BCM, its biomarkers, and both sexes: most likely nutrition, smoking, and alcohol intake. The results obtained with male data suggest a minor impact of sex-linked risk factors and, until recently, of treatment and early detection on BCM at the population level. Copyright 2000 American Health Foundation and Academic Press.
机译：背景：BCM与男女其他部位特异性癌症和心血管疾病的死亡率显着相关。这些其他死亡率可以用作BCM的独立生物标志物（预测因子），从而可以评估常见病因的重要性。方法：在1992年前后从全球37个国家/地区获得BCM（年龄调整后，年龄45-74岁），通过多变量回归进行估算，以找出最佳预测指标。结果：男性和女性生物标志物预测BCM的R（2）分别为0.80和0. 69。与男性结肠癌，前列腺癌，肺癌和直肠癌以及女性食道癌的相关性最强（R（2）= 0.84，P <0.0001）。前列腺癌对BCM的估计独立平均贡献百分比+/- SD为40 +/- 7（前列腺癌），38 +/- 9（男性结肠），13 +/- 6（男性肺癌和直肠癌）和9 +/- 3来自女性食道癌。回归方程（1992年数据）预测了1967年至1991年在28个可用国家中的平均BCM，平均误差为5％。从1967年至1991年，还可靠地预测了各个国家的BCM，r = 0.86至0.90（P <0.0001）。 1953年，r为0.74（P <0.0001）。结论：证据表明，BCM，其生物标志物和两性均常见的可改变环境因素的重大影响：最可能的营养，吸烟和酒精摄入量。从男性数据获得的结果表明，与性别相关的危险因素以及直到最近在人群水平上对BCM进行治疗和早期发现的影响较小。版权所有2000美国健康基金会和学术出版社。

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