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首页> 外文期刊>Preventive Medicine: An International Journal Devoted to Practice and Theory >Erectile dysfunction and coronary risk factors: prospective results from the Massachusetts male aging study.
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Erectile dysfunction and coronary risk factors: prospective results from the Massachusetts male aging study.

机译：勃起功能障碍和冠状动脉危险因素：马萨诸塞州男性衰老研究的前瞻性结果。

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BACKGROUND: Erectile dysfunction (ED), a wide spread and troublesome condition among middle-aged men, is partly vascular in origin. In the Massachusetts Male Aging Study, a random-sample cohort study, we investigated the relationship between baseline risk factors for coronary heart disease and subsequent ED, on the premise that subclinical arterial insufficiency might be manifested as ED. METHODS: Men ages 40-70, selected from state census lists, were interviewed in 1987-1989 and reinterviewed in 1995-1997. Data were collected and blood was drawn in participants' homes. ED was assessed from responses to a privately self-administered questionnaire. Analysis was restricted to 513 men with no ED at baseline and no diabetes, heart disease, or related medications at either time. RESULTS: Cigarette smoking at baseline almost doubled the likelihood of moderate or complete ED at followup (24% vs. 14%, adjusted for age and covariates, P = 0.01). Cigar smoking and passive exposure to cigarette smoke also significantly predicted incident ED, as did overweight (body-mass index > or =28 kg/m(2)) and a composite coronary risk score. Weaker prospective associations were seen for hypertension and dietary intake of cholesterol and unsaturated fat. CONCLUSIONS: Erectile dysfunction and coronary heart disease share some behaviorally modifiable determinants in men who, like our sample, are free of manifest ED or predisposing illness. Open questions include whether modification of coronary risk factors can prevent ED and whether ED may serve as a sentinel event for coronary disease. Copyright 2000 American Health Foundation and Academic Press.
机译：背景：勃起功能障碍（ED）是中年男性中广泛分布且麻烦的状况，部分起源于血管。在马萨诸塞州男性衰老研究（一项随机样本队列研究）中，我们在亚临床动脉功能不全可能表现为ED的前提下，调查了冠心病基线危险因素与随后的ED之间的关系。方法：从国家人口普查名单中选出40-70岁的男性，于1987-1989年进行了访谈，并于1995-1997年进行了重新访谈。收集数据并在参与者家中抽血。 ED是根据对私人自我管理问卷的回答进行评估的。分析仅限于513名基线时无ED，且任一时间均无糖尿病，心脏病或相关药物的男性。结果：基线时吸烟是中度或完全性ED的几率几乎翻倍（24％对14％，根据年龄和协变量调整，P = 0.01）。雪茄吸烟和被动吸烟会显着预测ED的发生，超重（体重指数≥28kg / m 2）和综合性冠心病危险评分也是如此。高血压，饮食中胆固醇和不饱和脂肪的摄入存在较弱的前瞻性关联。结论：勃起功能障碍和冠心病在男性中有一些行为可改变的决定因素，就像我们的样本一样，他们没有明显的ED或易患疾病。尚待解决的问题包括改变冠状动脉危险因素是否可以预防ED，以及ED是否可以作为冠心病的前哨事件。版权所有2000美国健康基金会和学术出版社。

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