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首页> 外文期刊>Preventive Medicine: An International Journal Devoted to Practice and Theory >Risk of type 2 diabetes mellitus in young adults from a biracial community: the Bogalusa Heart Study.
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Risk of type 2 diabetes mellitus in young adults from a biracial community: the Bogalusa Heart Study.

机译：来自混血儿社区的年轻人患2型糖尿病的风险：Bogalusa心脏研究。

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BACKGROUND: Since type 2 diabetes has a strong familial component, characteristics of young adult offspring of type 2 diabetics were examined in a community sample to determine early abnormalities in black and white persons at risk. METHODS: The sample consisted of 1,338 fasting young adults (72% white, 28% black) aged 19 to 37 years from a biracial community, including those with positive parental history of type 2 diabetes (one offspring per family, n = 230) or conditions of impaired fasting glucose and type 2 diabetes (n = 22). RESULTS: Positive family history of diabetes or impaired fasting glucose and type 2 diabetes in young adults of both races were significantly associated with adverse profiles of measures of obesity and abdominal fat (body mass index, triceps and subscapular skinfolds, waist circumference, and abdominal height), systolic and diastolic blood pressures, serum total cholesterol, triglycerides, VLDL cholesterol, and HDL cholesterol, and indicators of glucose homeostasis (plasma glucose and insulin and insulin resistance index). The magnitude of the differences in obesity and abdominal fat measures and plasma glucose between individuals with and without parental diabetes was greater among blacks versus whites (P = 0. 047-0.004). Further, black offspring of both diabetics and non-diabetics had unfavorable profiles of obesity and abdominal fat measures, blood pressure, insulin, and insulin resistance index (P = 0.0001). In a multivariate analysis, adiposity measured as body mass index (P = 0.03) and plasma glucose (P = 0.003) emerged as the two independent characteristics that distinguished those with parental diabetes from those without parental disease. Insulin (P = 0.0001) and the insulin resistance index (P = 0.0001) were independently associated with conditions of impaired fasting glucose or type 2 diabetes. CONCLUSIONS: The risk factors of young adults with parental type 2 diabetes or conditions of impaired fasting glucose and type 2 diabetes can be detected early. These observations have implications for early prevention and intervention, especially for blacks. Copyright 2000 American Health Foundation and Academic Press.
机译：背景：由于2型糖尿病具有强大的家族成分，因此在社区样本中检查了2型糖尿病的年轻成年后代的特征，以确定有风险的黑人和白人的早期异常。方法：该样本包括来自混血儿社区的19至37岁的1,338名空腹年轻人（72％的白人，28％的黑人），包括父母中有2型糖尿病父母史（每个家庭一个后代，n = 230）或空腹血糖受损和2型糖尿病的患者（n = 22）。结果：两个种族的年轻人中都有糖尿病的阳性家族史或空腹血糖受损和2型糖尿病与肥胖和腹部脂肪（体重指数，肱三头肌和肩cap下皮褶，腰围和腹部高度）的不良状况显着相关），收缩压和舒张压，血清总胆固醇，甘油三酸酯，VLDL胆固醇和HDL胆固醇，以及葡萄糖稳态的指标（血浆葡萄糖，胰岛素和胰岛素抵抗指数）。黑人与白人之间，有和没有父母亲糖尿病的个体之间，肥胖和腹部脂肪测量以及血浆葡萄糖差异的幅度更大（P = 0. 047-0.004）。此外，糖尿病人和非糖尿病人的黑人后代的肥胖和腹部脂肪测量，血压，胰岛素和胰岛素抵抗指数均不理想（P = 0.0001）。在多变量分析中，以体重指数（P = 0.03）和血浆葡萄糖（P = 0.003）衡量的肥胖表现出两个独立的特征，这些特征将父母型糖尿病患者和非父母型糖尿病患者区分开。胰岛素（P = 0.0001）和胰岛素抵抗指数（P = 0.0001）与空腹血糖受损或2型糖尿病的状况独立相关。结论：可以及早发现父母型2型糖尿病或空腹血糖受损和2型糖尿病的青年人的危险因素。这些观察结果对早期预防和干预具有影响，尤其是对黑人。版权所有2000美国健康基金会和学术出版社。

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