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首页> 外文期刊>Preventive Medicine: An International Journal Devoted to Practice and Theory >Validation of self-reported smoking status by simultaneous measurement of carbon monoxide and salivary thiocyanate.
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Validation of self-reported smoking status by simultaneous measurement of carbon monoxide and salivary thiocyanate.

机译：通过同时测量一氧化碳和唾液中的硫氰酸盐来验证自我报告的吸烟状况。

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OBJECTIVE: The objective of this study was to determine the validity of tobacco questionnaires when using as gold standard either a single biomarker or a combination of two biomarkers. METHODS: The methods were self-reported smoking compared with salivary thiocyanate and expired carbon monoxide in a 1996, population-based, Swiss survey of 552 men and 565 women. RESULTS: Sensitivity of self-reported smoking relative to salivary thiocynate or carbon monoxide alone was low (38.2% for salivary thiocyanate > or = 100 mg/L, 56.4% for salivary thiocyanate > or = 150 mg/L and 62.6% for carbon monoxide > or = 9 ppm). When defining true positive smokers as people with high concentration of both salivary thiocyanate and carbon monoxide, overall, sensitivity was 88.6% and specificity was 87.2%. In women, sensitivity increased from 85 to 89% when removing subjects exposed to passive smoking. When excluding heavy smokers, sensitivity decreased to 63% in men and to 71% in women. Older women had tendency to misreport smoking. CONCLUSIONS: This comparison of questionnaire data with the simultaneous measurement of salivary thiocyanate and expired carbon monoxide indicates that valid responses can be obtained for self-reported, current smoking in population-based surveys. However, the validity of questionnaires can be underestimated if the gold standard (of exposure to tobacco smoke) is either high levels of carbon monoxide or high levels of salivary thiocyanate. Copyright 2000 American Health Foundation and Academic Press.
机译：目的：本研究的目的是确定将单个生物标志物或两种生物标志物组合用作黄金标准时烟草问卷的有效性。方法：该方法是根据1996年在瑞士进行的一项针对552名男性和565名女性的人群调查，采用自我报告的吸烟方法与唾液中的硫氰酸盐和过期的一氧化碳进行比较。结果：自我报告吸烟相对于唾液硫氰酸盐或一氧化碳的敏感性低（唾液硫氰酸盐>或= 100 mg / L的为38.2％，唾液硫氰酸盐> = 150 mg / L的为56.4％，一氧化碳为62.6％ >或= 9 ppm）。当将真正的阳性吸烟者定义为唾液中的硫氰酸盐和一氧化碳含量都很高时，总体敏感性为88.6％，特异性为87.2％。在女性中，将被动吸烟者排除在外时，敏感性从85％提高到89％。当排除重度吸烟者时，男性的敏感性降至63％，女性的敏感性降至71％。老年妇女倾向于误报吸烟。结论：将问卷数据与唾液中的硫氰酸盐和过期的一氧化碳同时进行测量的比较表明，在基于人口的调查中，对于自我报告的当前吸烟可以获得有效的回答。但是，如果（接触烟草烟雾的）黄金标准是一氧化碳含量高或唾液中硫氰酸盐含量高，则问卷的有效性可能会被低估。版权所有2000美国健康基金会和学术出版社。

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