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首页> 外文期刊>Preventive Medicine: An International Journal Devoted to Practice and Theory >Biologic and epigenetic impact of commuting to work by car or using public transportation: A case-control study
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Biologic and epigenetic impact of commuting to work by car or using public transportation: A case-control study

机译：开车或使用公共交通工具上下班对生物和表观遗传的影响：病例对照研究

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Background and aims: Commuting by public transportation (PT) entails more physical activity and energy expenditure than by cars, but its biologic consequences are unknown. Methods: In 2009-2010, we randomly sampled New York adults, usually commuting either by car (n = 79) or PT (n = 101). Measures comprised diet and physical activity questionnaires, weight and height, white blood cell (WBC) count, C reactive protein, (CRP) gene-specific methylation (IL-6), and global genomic DNA methylation (LINE-1 methylation). Results: Compared to the 101 PT commuters, the 79 car drivers were about 9years older, 2kg/m 2 heavier, more often non-Hispanic whites, and ate more fruits and more meats. The 2005 guidelines for physical activity were met by more car drivers than PT users (78.5% vs. 65.0%). There were no differences in median levels of CRP (car vs. PT: 0.6 vs. 0.5mg/dl), mean levels of WBC (car vs. PT: 6.7 vs. 6.5cells/mm 3), LINE-1 methylation (car vs. PT: 78.0% vs. 78.3%), and promoter methylation of IL-6 (car vs. PT: 56.1% vs. 58.0%). Conclusions: PT users were younger and lighter than car drivers, but their commute mode did not translate into a lower inflammatory response or a higher DNA methylation, maybe because, overall, car drivers were more physically active.
机译：背景和目的：通过公共交通（PT）进行通勤比乘汽车进行更多的体力活动和能源消耗，但其生物学后果尚不清楚。方法：在2009-2010年，我们随机抽取纽约成年人，通常乘汽车（n = 79）或PT（n = 101）上下班。措施包括饮食和身体活动调查表，体重和身高，白细胞（WBC）计数，C反应蛋白，（CRP）基因特异性甲基化（IL-6）和总体基因组DNA甲基化（LINE-1甲基化）。结果：与101名PT通勤者相比，这79名汽车驾驶员大了9岁左右，体重增加了2kg / m 2，非西班牙裔白人更多，并且吃了更多的水果和更多的肉。与PT用户相比，更多的汽车驾驶员满足了2005年体育锻炼准则（78.5％对65.0％）。 CRP的中位数水平（汽车与PT：0.6与0.5mg / dl），WBC的平均水平（汽车与PT：6.7与6.5细胞/ mm 3），LINE-1甲基化（汽车）没有差异。与PT：78.0％与78.3％），以及IL-6的启动子甲基化（汽车与PT：56.1％与58.0％）。结论：PT使用者比汽车驾驶员年轻，轻便，但通勤模式并不能转化为较低的炎症反应或较高的DNA甲基化程度，这也许是因为总体而言，汽车驾驶员的身体活动能力更高。

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