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首页> 外文期刊>Preventive Medicine: An International Journal Devoted to Practice and Theory >Is Bacillus Calmette-Guerin revaccination necessary for Japanese children?
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Is Bacillus Calmette-Guerin revaccination necessary for Japanese children?

机译：日本儿童是否需要重新接种卡介苗芽孢杆菌？

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BACKGROUND: Bacillus Calmette-Guerin (BCG) revaccination has been implemented in Japan among tuberculin-negative first grade primary and first grade junior high school students for decades. Controversies regarding the effectiveness of BCG revaccination and low incidence of tuberculosis (TB) among Japanese children prompted this study. METHODS: Cost-effectiveness and cost-benefit analyses were conducted for a cohort of schoolchildren who underwent revaccination during 1996. The study population was a hypothetical cohort comprising 1.35 million first grade primary school and 1.51 million first grade junior high school students enrolled in 1996 at locations throughout Japan. Assuming 50% vaccine efficacy for revaccination, a 10-year duration of protection, and 5% annual discount rate, we calculated the total hypothetical number of TB cases averted, the cost and number of immunizations per TB case averted, and the benefit-cost ratio for the program. RESULTS: The revaccination program for 1996 schoolchildren cohort would prevent 296 TB cases over a 10-year period at a cost of US
机译：背景：几十年来，日本已经在结核菌素阴性的一年级小学和一年级初中学生中实施了卡介苗芽孢杆菌（BCG）的再接种。有关日本儿童中卡介苗再接种的有效性和结核病（TB）发生率低的争议促使了这项研究。方法：对1996年接受过疫苗接种的一组学龄儿童进行了成本效益和成本效益分析。研究人群是一个假设的队列，其中包括135万名一年级小学和151万名初中学生，于1996年入学。日本各地。假设重新接种疫苗的功效为50％，保护期为10年，每年贴现率为5％，我们计算了避免的结核病假想总数，避免的每结核病免疫接种的成本和次数以及收益成本程序的比率。结果：1996年小学生队列的再接种计划将在10年内预防296 TB病例，费用为美国

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