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首页> 外文期刊>Proceedings of the Nutrition Society >The quest for cardiovascular health in the genomic era: nutrigenetics and plasma lipoproteins
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The quest for cardiovascular health in the genomic era: nutrigenetics and plasma lipoproteins

机译：基因组时代对心血管健康的追求：营养遗传学和血浆脂蛋白

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Nutrigenetics and nutrigenomics are promising multidisciplinary fields that focus on studying the interactions between nutritional factors, genetic factors and health outcomes. Their goal is to achieve more efficient individual dietary intervention strategies aimed at preventing disease, improving quality of life and achieving healthy aging. Our studies, and those of many other investigators, using population-based and intervention studies have found evidence for interactions between dietary factors, genetic variants and biochemical markers of CVD. Now, the characterization of individuals who may respond better to one type of dietary recommendation than another can be begun. Thus, a low-fat low-cholesterol strategy may be particularly efficacious in lowering the plasma cholesterol levels of those subjects carrying the apoE4 allele at the APOE gene. HDL-cholesterol (HDL-C) levels are also modulated by dietary, behavioural and genetic factors. It has been reported that the effect of PUFA intake on HDL-C concentrations is modulated by an APOA1 genetic polymorphism. Thus, subjects carrying the A allele at the -75 G/A polymorphism show an increase in HDL-C with increased intakes of PUFA, whereas those homozygotes for the more common G allele have the expected lowering of HDL-C levels with increased intake of PUFA. Variability at the hepatic lipase gene is also associated with interactions between intake of fat and HDL-C concentrations that could shed some light on the different abilities of certain ethnic groups to adapt to new nutritional environments. This knowledge should lead to successful dietary recommendations partly based on genetic factors that may help to reduce cardiovascular risk more efficiently than the current universal recommendations.
机译：营养遗传学和营养基因组学是有前途的多学科领域，其重点是研究营养因子，遗传因子和健康结果之间的相互作用。他们的目标是实现更有效的个人饮食干预策略，以预防疾病，改善生活质量和实现健康的衰老。我们的研究以及许多其他研究者的研究，使用基于人群和干预的研究，已发现饮食因素，遗传变异和CVD的生化标志物之间相互作用的证据。现在，可以开始对一种类型的饮食建议比另一种类型的饮食建议做出更好反应的个体表征。因此，低脂低胆固醇策略在降低那些在APOE基因上携带apoE4等位基因的受试者的血浆胆固醇水平方面可能特别有效。高密度脂蛋白胆固醇（HDL-C）的水平也受到饮食，行为和遗传因素的调节。据报道，PUFA摄入对HDL-C浓度的影响是由APOA1遗传多态性调节的。因此，携带-75 G / A多态性的A等位基因的受试者显示，随着PUFA摄入量的增加，HDL-C升高，而那些更常见的G等位基因的纯合子则随着HDFA-C摄入量的增加，HDL-C水平有望降低。 PUFA。肝脂肪酶基因的变异性还与脂肪摄入和HDL-C浓度之间的相互作用有关，这可能会揭示某些族群适应新的营养环境的不同能力。这种知识应该部分地基于遗传因素导致成功的饮食建议，这些遗传因素可能比目前的普遍建议更有效地降低心血管风险。

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