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首页> 外文期刊>Proceedings of the Nutrition Society >Imaging methodologies and applications for nutrition research: what can functional MRI offer?
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Imaging methodologies and applications for nutrition research: what can functional MRI offer?

机译:营养研究的成像方法和应用:功能性MRI能提供什么?

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摘要

Food intake is influenced by a complex regulatory system involving the integration of a wide variety of sensory inputs across multiple brain areas. Over the past decade, advances in neuroimaging using functional MRI (fMRI) have provided valuable insight into these pathways in the human brain. This review provides an outline of the methodology of fMRI, introducing the widely used blood oxygenation level-dependent contrast for fMRI and direct measures of cerebral blood flow using arterial spin labelling. A review of fMRI studies of the brain's response to taste, aroma and oral somatosensation, and how fat is sensed and mapped in the brain in relation to the pleasantness of food, and appetite control is given. The influence of phenotype on individual variability in cortical responses is addressed, and an overview of fMRI studies investigating hormonal influences (e.g. peptide YY, cholecystokinin and ghrelin) on appetite-related brain processes provided. Finally, recent developments in MR technology at ultra-high field (7T) are introduced, highlighting the advances this can provide for fMRI studies to investigate the neural underpinnings in nutrition research. In conclusion, neuroimaging methods provide valuable insight into the mechanisms of flavour perception and appetite behaviour.
机译:食物的摄入量受复杂的监管系统影响,涉及跨多个大脑区域的多种感觉输入的整合。在过去的十年中,使用功能性MRI(fMRI)进行神经成像的进步为人脑中的这些途径提供了宝贵的见识。这篇综述概述了功能磁共振成像的方法,介绍了功能磁共振成像广泛使用的血液氧合水平依赖性对比剂,以及使用动脉自旋标记法直接测量脑血流量的方法。 fMRI研究综述了大脑对味觉,香气和口腔躯体感觉的反应,以及如何根据食物的愉悦性和控制食欲在大脑中感测和绘制脂肪。表型对皮层反应个体变异的影响得到解决,功能磁共振成像研究概述了激素对食欲相关的大脑过程的影响(例如肽YY,胆囊收缩素和生长素释放肽)。最后,介绍了超高场(7T)磁共振技术的最新进展,突出了这可以为功能磁共振成像研究提供营养研究中神经基础的研究进展。总之,神经影像学方法提供了对风味感知和食欲行为机理的宝贵见解。

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