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首页> 外文期刊>Proceedings of the Institution of Mechanical Engineers, Part H. Journal of Engineering in Medicine >Relating age and micro-architecture with apparent-level elastic constants: a micro-finite element study of female cortical bone from the anterior femoral midshaft
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Relating age and micro-architecture with apparent-level elastic constants: a micro-finite element study of female cortical bone from the anterior femoral midshaft

机译：与年龄和微观结构与表观水平的弹性常数相关：来自股骨前中轴的女性皮质骨的微观有限元研究

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Homogenized elastic properties are often assumed for macro-finite element (FE) models used in orthopaedic biomechanics. The accuracy of material property assignments may have a strong effect on the ability of these models to make accurate predictions. For cortical bone, most macro-scale FE models assume isotropic elastic material behaviour and do not include variation of material properties due to bone micro-architecture. The first aim of the present study was to evaluate the variation of apparent-level (homogenized) orthotropic elastic constants of cortical bone with age and indices of bone micro-architecture. Considerable age-dependent differences in porosity were noted across the cortical thickness in previous research. The second aim of the study was to quantify the resulting differences in elastic constants between the periosteum and endosteum. Specimens were taken from the anterior femoral midshaft of 27 female donors (age 53.4 ± 23.6 years) and micro-FE (μFE) analysis was used to derive orthotropic elastic constants. The variation of orthotropic elastic constants (Young's moduli, shear moduli, and Poisson's ratios) with various cortical bone micro-architectural indices was investigated. The ratio of canal volume to tissue volume, Ca.V/TV, analogous to porosity, was found to be the strongest predictor (r_(ave)~2 = 0.958) of the elastic constants. Age was less predictive (r_(ave)~2 = 0.385) than Ca.V/TV. Elastic anisotropy increased with increasing Ca.V/TV, leading to lower elastic moduli in the transverse, typically less frequently loaded, directions. Increased Ca.V/TV led to a more substantial reduction in elastic constants at the endosteal aspect than at the periosteal aspect. The results are expected to be most applicable in similar midshaft locations of long bones; specific analysis of other sites would be necessary to evaluate elastic properties elsewhere. It was concluded that Ca.V/TV was the most predictive of cortical bone elastic constants and that considerable periosteal-endosteal variations in these constants can develop with bone loss.
机译：整形外科的生物力学中通常使用均质弹性特性（FE）模型。材料属性分配的准确性可能会对这些模型做出准确预测的能力产生重大影响。对于皮质骨，大多数宏观有限元模型都假设各向同性的弹性材料行为，并且不包括由于骨微结构而引起的材料性能变化。本研究的第一个目的是评估皮质骨的表观水平（均质）正交各向异性弹性常数随年龄和骨微结构指数的变化。在先前的研究中，在整个皮质厚度上都发现了孔隙度随年龄的显着差异。该研究的第二个目的是量化骨膜和骨膜之间弹性常数的差异。标本取自27位女性供体的股骨前中轴（年龄53.4±23.6岁），并使用micro-FE（μFE）分析得出正交各向异性弹性常数。研究了正交各向异性弹性常数（杨氏模量，剪切模量和泊松比）随皮质骨微结构指标的变化。根管体积与组织体积之比，Ca.V / TV，类似于孔隙率，是弹性常数的最强预测因子（r_（ave）〜2 = 0.958）。与Ca.V / TV相比，年龄的预测性差（r_（ave）〜2 = 0.385）。弹性各向异性随Ca.V / TV的增加而增加，从而导致横向（通常加载频率较低）方向上的弹性模量降低。 Ca.V / TV的增加导致骨内膜方面的弹性常数比骨膜方面的弹性更显着降低。预期结果将最适用于长骨的类似中轴位置;其他部位的具体分析对于评估其他部位的弹性性能很有必要。结论是，Ca.V / TV是最能预测皮质骨弹性常数的，并且随着骨质流失，这些常数可能会在骨膜-内膜之间发生大量变化。

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