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首页> 外文期刊>Proceedings of the Institution of Mechanical Engineers, Part H. Journal of Engineering in Medicine >An innovative shape equation to quantify the morphological characteristics of parasitized red blood cells by Plasmodium falciparum and Plasmodium vivax
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An innovative shape equation to quantify the morphological characteristics of parasitized red blood cells by Plasmodium falciparum and Plasmodium vivax

机译：创新的形状方程式可量化恶性疟原虫和间日疟原虫寄生的红细胞的形态特征

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摘要

The morphology of red blood cells is affected significantly during maturation of malaria parasites, Plasmodium falciparum and Plasmodium vivax. A novel shape equation is presented that defines shape of parasitized red blood cells by P. falciparum(Pf-red blood cells) and P. vivax (Pv-red blood cells) at four stages of infection. The Giemsa-stained thin blood films are prepared using blood samples collected from healthy donors, patients having P. falciparum and P. vivax malaria. The diameter and thickness of healthy red blood cells plus Pf-red blood cells and Pv-red blood cells at each stage of infection are measured from their optical images using Olysia and Scanning Probe Image Processor softwares, respectively. Using diameters and thicknesses of parasitized red blood cells, a shape equation is fitted and relative two-dimensional shapes are plotted using MATHEMATICA. The shape of Pf-red blood cell drastically changes at ring stage as its thickness increases by 82%, while Pv-red blood cell remains biconcave (30% increase in thickness). By trophozoite and subsequent schizont stage, the Pf-red blood cell entirely loses its biconcave shape and becomes near spherical (diameter and thickness of ~8 mm). The Pv-red blood cell remains biconcave throughout the parasite development even though its volume increases. These results could have practical use for faster diagnosis, prediction, and treatment of human malaria and sickle-cell diseases.
机译：在疟原虫，恶性疟原虫和间日疟原虫成熟期间，红细胞的形态会受到显着影响。提出了一个新的形状方程，该方程定义了在四个感染阶段由恶性疟原虫（Pf-红细胞）和间日疟原虫（Pv-红细胞）定义的寄生红细胞的形状。使用从健康供体，恶性疟原虫和间日疟原虫疟疾患者收集的血液样本制备吉姆萨染色的薄血膜。在感染的每个阶段，分别使用Olysia和Scanning Probe Image Processor软件根据其光学图像测量健康红细胞，Pf-红细胞和Pv-红细胞的直径和厚度。使用被寄生的红细胞的直径和厚度，拟合形状方程，并使用MATHEMATICA绘制相对的二维形状。随着厚度增​​加82％，Pf-红血球的形状在环形阶段急剧变化，而Pv-红血球保持双凹（厚度增加30％）。通过滋养体和随后的裂殖体阶段，Pf-红血细胞完全失去了其双凹的形状，变成接近球形（直径和厚度约为8 mm）。即使其体积增加，Pv-红细胞在整个寄生虫发育过程中仍保持双凹。这些结果可用于更快地诊断，预测和治疗人类疟疾和镰状细胞疾病。

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