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首页> 外文期刊>Proceedings of the Institution of Mechanical Engineers, Part H. Journal of Engineering in Medicine >Polymer surface properties and their effect on the adhesion of Proteus mirabilis
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Polymer surface properties and their effect on the adhesion of Proteus mirabilis

机译：聚合物表面特性及其对变形杆菌变形的附着力的影响

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摘要

A problem encountered in patients undergoing long-term catheteri7ation of the urinary tract is that of encrustation and blockage of the catheter by crystalline bacterial biofilms. This is principally caused by the action of the urease-producing pathogen Proteus mirabilis. A major aim of this work is to develop materials resistant to encrustation. Here, the effects of polymer surface properties on the adhesion of P. mirabilis are examined. Spin-coated polymer films were characterized through contact angle measurements to give the Lifschitz-van der Waals, electron acceptor and electron donor terms of the surface free energy, γ{sub}s{sup}(LW), γ{sub}s{sup}+ and γ{sub}s{sup}- respectively. A parallel-plate flow cell was used to assess adhesion to these polymer films of P. mirabilis suspended in an aqueous phosphate buffer, pH 7.4, ionic strength 0.26 mol/kg. P. mirabilis was found to adhere significantly less (p < 0.02) to films of agarose, poly(2-hydroxyethylmethacrylate) and cross-linked poly(vinyl alcohol ) than to more hydrophobic materials. These polymer films were found to be strongly electron donating, i.e. possessing large γ{sub}s{sup}-. Films examined using scanning electron microscopy mostly showed no evidence of roughness down to a scale of 1-10 μm. The better performance is thought to be due to a repulsive interaction with the bacterial surface caused by acid/base-type interactions.
机译：在对尿道进行长期导管插入术的患者中遇到的问题是结晶细菌生物膜对导管的结壳和阻塞。这主要是由产生脲酶的病原菌Proteus mirabilis的作用引起的。这项工作的主要目的是开发抗结垢的材料。在这里，检查了聚合物表面性质对奇异假单胞菌粘附的影响。通过接触角测量来表征旋涂的聚合物薄膜，以给出表面自由能的γ{sub} s {sup}（LW），γ{sub} s {的Lifschitz-van der Waals，电子受体和电子供体项。 sup} +和γ{sub} s {sup}-。使用平行板流动池评估悬浮在pH 7.4，离子强度0.26 mol / kg的水性磷酸盐缓冲液中的奇异假单胞菌对这些聚合物膜的附着力。发现奇异假单胞菌与琼脂糖，聚（甲基丙烯酸2-羟乙基酯）和交联的聚乙烯醇的膜相比，与疏水性更高的材料相比，其附着力明显更少（p <0.02）。发现这些聚合物膜是强电子给体的，即具有大的γ{sub} s {sup}-。使用扫描电子显微镜检查的薄膜大多没有证据表明粗糙度低至1-10μm。认为更好的性能是由于酸/碱型相互作用引起的与细菌表面的排斥性相互作用。

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