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首页> 外文期刊>Proceedings of the Institution of Mechanical Engineers, Part H. Journal of Engineering in Medicine >Albumin and fibronectin protein adsorption on CO{sub}2-laser-modified biograde stainless steel
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Albumin and fibronectin protein adsorption on CO{sub}2-laser-modified biograde stainless steel

机译：白蛋白和纤连蛋白蛋白在CO {sub} 2-激光改性生物级不锈钢上的吸附

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摘要

The surface properties of a biomaterial play an essential role in protein adsorption, which in turn determines the cellular response to the adsorbed surface. In order to obtain a surface that would yield favourable protein adsorption for successful cellular response, the surface properties of a biograde stainless steel were modified by CO{sub}2 laser treatment. An investigation of the CO{sub}2-laser-modified surface properties and the effects thereof on the adsorption of human serum albumin (no-cell adhesive) and human plasma fibronectin (cell adhesive) was conducted. It was found that the thickness of the adsorbed fibronectin layer increased with increasing CO{sub}2 laser power density, while the thickness of the adsorbed albumin layer decreased with increasing CO{sub}2 laser power density. The surface roughness and wettability characteristics contributed to the observed changes in protein adsorption. The wettability characteristics of the biograde stainless steel were found to be the predominant mechanism governing the observed change in protein adsorption. Since the wettability characteristics of the biograde stainless steel can be modified in an efficient and controllable way with the CO{sub}2 laser, it is believed that this work presents a demonstrable alternative to the techniques currently available for enhancing the biocompatibility of biograde stainless steels.
机译：生物材料的表面特性在蛋白质吸附中起着至关重要的作用，而蛋白质的吸附又决定了细胞对吸附表面的反应。为了获得能够产生有利于成功的细胞应答的良好蛋白质吸附的表面，通过CO {sub} 2激光处理对生物级不锈钢的表面性能进行了改性。进行了CO {sub} 2-激光修饰的表面性质及其对人血清白蛋白（无细胞粘合剂）和人血浆纤连蛋白（细胞粘合剂）的吸附的影响的研究。发现随着CO {sub} 2激光功率密度的增加，吸附的纤连蛋白层的厚度增加，而随着CO {sub} 2激光功率密度的增加，吸附的白蛋白层的厚度减小。表面粗糙度和润湿性特征有助于观察到蛋白质吸附的变化。发现生物级不锈钢的润湿性特征是控制观察到的蛋白质吸附变化的主要机理。由于可以使用CO {sub} 2激光以有效且可控的方式修改生物级不锈钢的润湿特性，因此，可以相信这项工作为目前可用于增强生物级不锈钢的生物相容性的技术提供了可证明的替代方案。 。

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