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首页> 外文期刊>Progres en urologie: journal de l’Association francaise d’urologie et de la Societefrancaise d’urologie >Sexual dysfunctions linked with prostatic diseases [Troubles sexuels associés aux maladies de la prostate]
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Sexual dysfunctions linked with prostatic diseases [Troubles sexuels associés aux maladies de la prostate]

机译：性功能障碍与前列腺疾病有关

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Introduction: The lower urinary tract symptoms (LUTS) related to benign prostatic hyperplasia (BPH) and the treatment of prostate cancer (PCa) are linked to erectile dysfunction (ED). The objective of this work was to evaluate the influence of prostatic diseases on ED. Materials and method: Data on the influence of BPH and PCa on ED have been explored in Medline and Embase using the MeSH keywords : benign prostatic hyperplasia, prostate cancer, prostatectomy, external beam radiotherapy ; androgen deprivation therapy ; erectile dysfunction. The articles were selected based on their methodology, relevance, date and language of publication. Results: The rate of ED in patients with BPH ranged from 30 to 70 %. The LUTS were an independent risk factor of ED. The pathophysiology linking BPH to ED has not been elucidated but seems to involve the path of Nitric Oxide - cyclic Guanosine Monophosphate (cGMP-No.), the RhoA - Rho - Kinase (ROCK) signal, the sympathetic autonomic nervous system and pelvic atherosclerosis. The rate of ED after radical prostatectomy (RP) ranged from 60 to 89 %. The bilateral preservation of neurovascular bundels improved these results. Risk factors of ED after RP were age, PSA levels, pretreatment erectile function and surgical technique. The rate of ED after prostate external beam radiotherapy ranged from 6 to 84 %. Risk factors of ED after external beam radiotherapy were age, pretreatment erectile function and association of androgen deprivation therapy. The rate of ED with androgen deprivation therapy was 85 %. Risk factors of ED with androgen deprivation therapy were age > 70 years, diabetes and pretreatment erectile function. Intermittent androgen deprivation therapy was associated with better results on erectile function than continue androgen deprivation therapy. Conclusion: ED is responsible for a decrease of elderly patients life quality already affected by urinary symptoms and prostate disease progression. The development of drugs effective on both ED and BPH or PCa symptoms is then full of meaning.
机译：简介：与良性前列腺增生（BPH）相关的下尿路症状（LUTS）和前列腺癌（PCa）的治疗与勃起功能障碍（ED）相关。这项工作的目的是评估前列腺疾病对ED的影响。材料和方法：在Medline和Embase中使用MeSH关键字探讨了BPH和PCa对ED的影响的数据：MeSH关键字：良性前列腺增生，前列腺癌，前列腺切除术，外照射;雄激素剥夺治疗;勃起功能障碍。根据文章的方法，相关性，出版日期和语言选择文章。结果：BPH患者的ED发生率在30％至70％之间。 LUTS是ED的独立危险因素。将BPH与ED关联的病理生理学尚未阐明，但似乎涉及一氧化氮-环状鸟苷单磷酸（cGMP-No。），RhoA-Rho-激酶（ROCK）信号，交感植物神经系统和盆腔动脉粥样硬化的路径。根治性前列腺切除术（RP）后ED的发生率在60％至89％之间。神经血管束的双边保存改善了这些结果。 RP后ED的危险因素为年龄，PSA水平，治疗前勃起功能和手术技术。前列腺外束放射治疗后ED的发生率在6％至84％之间。外照射治疗后ED的危险因素是年龄，治疗前的勃起功能和雄激素剥夺治疗的关联。 ED与雄激素剥夺治疗的比率为85％。雄激素剥夺治疗ED的危险因素是年龄> 70岁，糖尿病和治疗前勃起功能。间歇性雄激素剥夺治疗比持续雄激素剥夺治疗具有更好的勃起功能。结论：ED导致已经受泌尿症状和前列腺疾病进展影响的老年患者生活质量下降。这样，对ED和BPH或PCa症状均有效的药物的开发就具有意义。

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