Crystal structures of three representatives of a new Pfam family PF14869 (DUF4488) suggest they function in sugar binding/uptake

Kumar Abhinav; Punta Marco; Axelrod Herbert L.; Das Debanu; Farr Carol L.; Grant Joanna C.; Chiu Hsiu-Ju; Miller Mitchell D.; Coggill Penelope C.; Klock Heath E.; Elsliger Marc-Andre; Deacon Ashley M.; Godzik Adam; Lesley Scott A.; Wilson Ian A.

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Crystal structures of three representatives of a new Pfam family PF14869 (DUF4488) suggest they function in sugar binding/uptake

机译：新的Pfam家族PF14869（DUF4488）的三个代表的晶体结构表明它们在糖结合/摄取中起作用

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Crystal structures of three members (BACOVA_00364 from Bacteroides ovatus, BACUNI_03039 from Bacteroides uniformis and BACEGG_00036 from Bacteroides eggerthii) of the Pfam domain of unknown function (DUF4488) were determined to 1.95, 1.66, and 1.81 angstrom resolutions, respectively. The protein structures adopt an eight-stranded, calycin-like, beta-barrel fold and bind an endogenous unknown ligand at one end of the beta-barrel. The amino acids interacting with the ligand are not conserved in any other protein of known structure with this particular fold. The size and chemical environment of the bound ligand suggest binding or transport of a small polar molecule(s) as a potential function for these proteins. These are the first structural representatives of a newly defined PF14869 (DUF4488) Pfam family.

机译：确定了功能未知的Pfam域（DUF4488）的三个成员的晶体结构（卵形拟杆菌的BACOVA_00364，卵形拟杆菌的BACUNI_03039和卵形拟杆菌的BACEGG_00036）的晶体结构分别为1.95、1.66和1.81埃分辨率。蛋白质结构采用八链，类似花萼素的β-桶折叠，并在β-桶的一端结合内源性未知配体。与配体相互作用的氨基酸在具有该特定折叠的任何其他已知结构的蛋白质中均不保守。结合的配体的大小和化学环境表明小极性分子的结合或转运是这些蛋白质的潜在功能。这些是新定义的PF14869（DUF4488）Pfam系列的第一个结构代表。

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《Protein Science: A Publication of the Protein Society》 |2014年第10期|共12页
作者
Kumar Abhinav; Punta Marco; Axelrod Herbert L.; Das Debanu; Farr Carol L.; Grant Joanna C.; Chiu Hsiu-Ju; Miller Mitchell D.; Coggill Penelope C.; Klock Heath E.; Elsliger Marc-Andre; Deacon Ashley M.; Godzik Adam; Lesley Scott A.; Wilson Ian A.;
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正文语种 eng
中图分类生物化学;
关键词
Bacteroides; DUF4488; sugar binding; calycins; unknown ligand; crystal structure;

机译：拟杆菌;DUF4488;糖结合;花萼素;未知配体;晶体结构;

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1. Crystal structures of three representatives of a new Pfam family PF14869 (DUF4488) suggest they function in sugar binding/uptake [J] . Kumar Abhinav, Punta Marco, Axelrod Herbert L., Protein Science: A Publication of the Protein Society . 2014,第10期

机译：新的Pfam家族PF14869（DUF4488）的三个代表的晶体结构表明它们在糖结合/摄取中起作用
2. Crystal structures of the sugar complexes of Streptomyces olivaceoviridis E-86 xylanase: sugar binding structure of the family 13 carbohydrate binding module. [J] . Fujimoto Z, ffrc.go.jp, Kuno A, Journal of Molecular Biology . 2002,第1期

机译：寡链链霉菌E-86木聚糖酶的糖复合物的晶体结构：家族13糖结合模块的糖结合结构。
3. Synthesis, crystal structures and competitive binding property of a family of functionalized calix[4]arene ionophores [J] . Vallu Ramakrishna, Subrata Patra, E. Suresh Inorganic Chemistry Communications . 2012,第Null期

机译：一族功能化杯[4]芳烃离子载体的合成，晶体结构和竞争结合性能
4. The structure and function of carbohydrate recognition proteins,carbohydrate-binding module of celJ from Clostridium thermocellum and sugar-recognizing ubiqiutin ligase [C] . China-Japan-Korea Joint Symposium on Enzyme Engineering . 2004

机译：热纤梭菌中的碳水化合物识别蛋白，celJ的碳水化合物结合模块和识别糖的泛酸连接酶的结构和功能
5. Evolution, structure and stability studies of bacteriorhodopsin mutants and crystallographic studies of a sugar-binding membrane protein from the hyperthermophile Pyrobaculum aerophilum. [D] . Yohannan, Sarah Jennifer. 2004

机译：细菌视紫红质突变体的进化，结构和稳定性研究以及嗜热嗜热菌嗜热菌嗜糖结合膜蛋白的晶体学研究。
6. Crystal structures of three representatives of a new Pfam family PF14869 (DUF4488)suggest they function in sugar binding/uptake [O] . Abhinav Kumar, Marco Punta, Herbert L Axelrod, 2014

机译：新型Pfam系列PF14869（DUF4488）的三个代表的晶体结构表明它们在糖结合/摄取中起作用
7. The structure of SSO2064, the first representative of Pfam family PF01796, reveals a novel two-domain zinc-ribbon OB-fold architecture with a potential acyl-CoA-binding role [O] . Krishna, S. Sri, Aravind, L., Bakolitsa, Constantina, 2010

机译：Sf2064的结构是Pfam家族PF01796的第一个代表，揭示了一种新型的两结构域锌带OB折叠结构，具有潜在的酰基辅酶A结合作用

Crystal structures of three representatives of a new Pfam family PF14869 (DUF4488) suggest they function in sugar binding/uptake

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