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Oncogene-induced cellular senescence elicits an anti - Warburg effect

机译：癌基因诱导的细胞衰老引发抗Warburg效应

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摘要

Oncogene-induced senescence is now recognized as being an important mechanism in protecting against cancer. The phenotypic consequences, i.e., the inhibition of cell proliferation, are well described in model systems and specific events/key players defined. However, there is still the need to understand, at a more global level, the network of events involved both in terms of cause and consequence. This paper shows the power of systematic proteomic analyses, both targeted and global, in addressing such biological questions, highlighting the widespread nature of histone acetylation changes, and the opposite metabolic changes to those seen in the Warburg effect.
机译：现在，癌基因诱导的衰老被认为是预防癌症的重要机制。表型后果，即抑制细胞增殖，在模型系统和定义的特定事件/关键参与者中得到了很好的描述。但是，仍然有必要在更全球化的水平上理解因果关系所涉及的事件网络。本文展示了针对性和全局性系统蛋白质组分析在解决此类生物学问题上的能力，突出了组蛋白乙酰化变化的广泛性质以及与Warburg效应相反的代谢变化。

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