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首页> 外文期刊>Proteomics >Elastic image registration of 2-D gels for differential and repeatability studies.
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Elastic image registration of 2-D gels for differential and repeatability studies.

机译：二维凝胶的弹性图像配准，用于差异和重复性研究。

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摘要

One of the main applications of electrophoretic 2-D gels is the analysis of differential responses between different conditions. For this reason, specific spots are present in one of the images, but not in the other. In some other occasions, the same experiment is repeated between 2 and 12 times in order to increase statistical significance. In both situations, one of the major difficulties of these analysis is that 2-D gels are affected by spatial distortions due to run-time differences and dye-front deformations, resulting in images that are significantly dissimilar not only because of their content, but also because of their geometry. In this technical brief, we show how to use free, state-of-the-art image registration and fusion algorithms developed by us for solving the problem of comparing differential expression profiles, or computing an "average" image from a series of virtually identical gels.
机译：电泳二维凝胶的主要应用之一是分析不同条件之间的差异反应。因此，在一个图像中存在特定的斑点，而在另一个图像中则没有。在其他一些情况下，同一实验重复2到12次以提高统计意义。在这两种情况下，这些分析的主要困难之一是2-D凝胶受运行时间差异和染料前缘变形的影响而受到空间畸变的影响，导致图像的差异不仅在于其含量，而且还因为它们的含量而显着不同。也因为它们的几何形状。在本技术简介中，我们展示了如何使用我们开发的免费的最新图像配准和融合算法来解决比较差异表达谱或从一系列几乎相同的图像中计算“平均”图像的问题凝胶。

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