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首页> 外文期刊>Psychiatric genetics >Analysis of polymorphisms in the alpha-subunit of the olfactory G-protein Golf in lithium-treated bipolar patients.
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Analysis of polymorphisms in the alpha-subunit of the olfactory G-protein Golf in lithium-treated bipolar patients.

机译：锂治疗的双相型患者嗅觉G蛋白高尔夫的α亚基的多态性分析。

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OBJECTIVEThis study examines the alpha-subunit of the olfactory G-protein (G(olf)) as a possible candidate gene for bipolar disorder. The alpha-subunit of the G(olf) gene maps to a region on chromosome 18p that has been implicated in several linkage studies as a potential site of a bipolar disorder susceptibility loci.METHODSWe investigated whether two polymorphisms in the alpha-subunit of the G(olf) gene (A-->G in intron 3 and T-->G in intron 10) are associated with bipolar disorder in a sample of 149 bipolar patients under lithium treatment compared with 139 healthy controls using haplotype analysis.RESULTSThere was no evidence for an association between the investigated polymorphisms in the G(olf) gene and bipolar disorders, as well as to response to lithium treatment or common side effects, like hand tremor, weight gain and cognitive dysfunction.CONCLUSIONThe results of the present study do not support the hypothesis that the G(olf) gene is a major susceptibility factor for bipolar disorders.
机译：目的这项研究研究了嗅觉G蛋白（G（olf））的α亚基，它可能是双相情感障碍的候选基因。 G（olf）基因的α-亚基映射到18p染色体上的一个区域，该区域已在几项连锁研究中作为双相情感障碍易感基因座的潜在位点。与单倍型分析的139名健康对照相比，在149名接受锂治疗的双相患者中，（olf）基因（内含子3中的A-> G和内含子10中的T-> G）与双相情感障碍有关。研究中G（olf）基因多态性与躁郁症之间的关联以及对锂治疗或常见副作用（如手震，体重增加和认知功能障碍）的反应之间存在关联的证据。结论本研究的结果并未支持G（olf）基因是双相情感障碍的主要易感因素的假设。

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