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DAT polymorphism and diverse clinical manifestations in methamphetamine abusers.

机译：DAT多态性和甲基苯丙胺滥用者的多种临床表现。

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The clinical outcome for methamphetamine (MAP) abusers is variable. MAP exerts its biological activity through rapid conversion to amphetamine (AP) and MAP itself. The dopamine transporter (DAT) is the main modulator of MAP/AP-induced dopamine release and dopamine neurotoxicity, and is also the major regulator of dopamine level in the brain. We tested for an association between a DAT-gene polymorphism and clinical variations in MAP abusers. A total of 146 MAP abusers were enrolled in the study and classified into three clinically distinct groups: MAP dependence (n = 30), MAP psychosis (n = 88) and chronic MAP psychosis (n = 28). Patients with schizophrenia (n = 79) and healthy controls (n = 72) were also recruited for the study. The 40 base pair variable number tandem repeat polymorphism in the 3'-untranslated region of the DAT was the focus of the investigation. The subjects were all Chinese residents of Taiwan. The respective allelic frequencies for DAT repeats 11, 10 and 9 were 0.067, 0.833 and 0.083 for the MAP-dependence group, 0.006, 0.864 and 0.119 for the MAP psychosis group, 0.018, 0.893 and 0.089 for the chronic MAP psychosis group, 0.019, 0.911 and 0.07 for the schizophrenic controls, and 0.021, 0.889 and 0.083 for the healthy controls. No significant associations were demonstrated between this DAT polymorphism in genotype and allele frequency and the clinical outcome of MAP abusers. The biological relevance of the variable number tandem repeat polymorphism in the 3'-untranslated region of DAT in MAP abusers was not demonstrated in this study.
机译：甲基苯丙胺（MAP）滥用者的临床结果是可变的。 MAP通过快速转化为苯丙胺（AP）和MAP本身来发挥其生物学活性。多巴胺转运蛋白（DAT）是MAP / AP诱导的多巴胺释放和多巴胺神经毒性的主要调节剂，也是大脑中多巴胺水平的主要调节剂。我们测试了DAT基因多态性与MAP滥用者的临床变异之间的关联。总共146名MAP滥用者被纳入研究，并分为三个临床上不同的组：MAP依赖（n = 30），MAP精神病（n = 88）和慢性MAP精神病（n = 28）。还招募了患有精神分裂症（n = 79）和健康对照（n = 72）的患者。 DAT 3'-非翻译区的40个碱基对的可变数目串联重复多态性是研究的重点。受试者都是台湾的中国居民。对于MAP依赖组，DAT重复11、10和9的等位基因频率分别为0.067、0.833和0.083，对于MAP精神病组分别为0.006、0.864和0.119，对于慢性MAP精神病组分别为0.018、0.893和0.089,0.019，精神分裂症对照组为0.911和0.07，健康对照组为0.021、0.889和0.083。 DAT基因型和等位基因频率的多态性与MAP滥用者的临床结局之间没有显着相关性。在这项研究中未证明DAT的3'-非翻译区中可变数目的串联重复重复多态性的生物学相关性。

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