Re-analysis of Collaborative Study on the Genetics of Alcoholism pedigrees suggests the presence of loci influencing novelty-seeking near D12S391 and D17S1299.

Curtis D

首页> 外文期刊>Psychiatric genetics >Re-analysis of Collaborative Study on the Genetics of Alcoholism pedigrees suggests the presence of loci influencing novelty-seeking near D12S391 and D17S1299.

【24h】

Re-analysis of Collaborative Study on the Genetics of Alcoholism pedigrees suggests the presence of loci influencing novelty-seeking near D12S391 and D17S1299.

机译：对酒精中毒家系遗传学合作研究的重新分析表明，存在着影响D12S391和D17S1299附近寻求新颖性的基因座。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

A previous genome scan using variance components analysis of 758 sib pairs from families of alcoholics found evidence for linkage of harm avoidance (HA) to markers on 8p21-23, and this finding was supported in a subsequent linkage study of 384 sib pairs. Here the original dataset is analysed using a new method of linkage analysis for quantitative traits that deals with extended pedigrees. As well as supporting linkage of HA to D8S549, this method also produces an MALOD of 2.4 (P=0.002) near DBH and several positive lod scores for novelty-seeking, the largest being MALODs of 3.1 (P=0.0004) near D12S391 and 3.4 (P=0.0003) near D17S1299. There is no support for linkage of novelty-seeking or HA to the regions around DRD4 and 5HTT, respectively. Additional samples will need to be studied in order to discover which regions truly harbour genetic polymorphisms influencing personality traits.

机译：先前使用来自酗酒者家族的758个同胞对的方差成分分析进行的基因组扫描，发现了避免伤害（HA）与8p21-23上的标记连锁的证据，这一发现在随后的384个同胞对的连锁研究中得到了支持。在这里，使用链接分析的新方法对原始数据集进行分析，以处理涉及扩展谱系的数量性状。除了支持HA与D8S549的连接外，该方法还在DBH附近产生2.4的MALOD（P = 0.002），并为寻求新颖性提供了几个积极的lod得分，最大的是D12S391和3.4附近的MALOD 3.1的POD = 0.0004。（P = 0.0003）在D17S1299附近。不支持将寻求新颖性或HA分别链接到DRD4和5HTT周围的区域。为了发现哪些地区确实具有影响人格特质的遗传多态性，将需要研究其他样本。

著录项

来源
《Psychiatric genetics》 |2004年第3期|共5页
作者
Curtis D;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类神经病学与精神病学;
关键词
Sjogren's syndrome B antibody; Pedigree; Analysis of substances; 系谱;

机译：干燥综合征B抗体;谱系;物质分析;系谱;

相似文献

外文文献
专利

1. Re-analysis of Collaborative Study on the Genetics of Alcoholism pedigrees suggests the presence of loci influencing novelty-seeking near D12S391 and D17S1299. [J] . Curtis D Psychiatric genetics . 2004,第3期

机译：对酒精中毒家系遗传学合作研究的重新分析表明，存在着影响D12S391和D17S1299附近寻求新颖性的基因座。
2. Genome scan of pedigrees multiply affected with bipolar disorder provides further support for the presence of a susceptibility locus on chromosome 12q23-q24, and suggests the presence of additional loci on 1p and 1q. [J] . Curtis D, Kalsi G, Brynjolfsson J, Psychiatric genetics . 2003,第2期

机译：对患有双相情感障碍的家系繁殖的基因组扫描为染色体12q23-q24上易感性基因座的存在提供了进一步的支持，并暗示了在1p和1q上存在额外的基因座。
3. No association of the GABAA receptor genes on chromosome 5 with alcoholism in the collaborative study on the genetics of alcoholism sample. [J] . Dick DM, Edenberg HJ, Xuei X, American journal of medical genetics, Part B. Neuropsychiatric genetics: the official publication of the International Society of Psychiatric Genetics . 2005,第1期

机译：在酒精中毒样本遗传学的合作研究中，第5号染色体上的GABAA受体基因与酒精中毒没有关联。
4. COMBINING TWO MARKOV CHAIN MONTE CARLO APPROACHES FOR LINKAGE AND ASSOCIATION STUDIES WITH A COMPLEX PEDIGREE AND MULTI MARKER LOCI [C] . S.H. Lee, J.H.J. Van der Werf, B. Tier Conference of the Association of the Advancement of Animal Breeding and Genetics . 2005

机译：用复杂的谱系和多标记基因座结合两种马尔可夫链蒙特卡罗接近联系和关联研究的方法
5. Genomic mapping of leaf rust and stem rust resistance loci in durum wheat and use of RAD-Genotype by Sequencing for the study of population genetics in Puccinia triticina [D] . Aoun, Meriem. 2016

机译：杜兰姆小麦叶片锈病和茎锈抗性基因座的基因组映射及吡锡群群体遗传学研究的用途抗基因型
6. Comparison of single-nucleotide polymorphisms and microsatellites in detecting quantitative trait loci for alcoholism: The Collaborative Study on the Genetics of Alcoholism [O] . Helen Kim, Carolyn M Hutter, Stephanie A Monks, 2005

机译：比较单核苷酸多态性和微卫星检测酒精中毒的数量性状基因座：酒精中毒遗传学的合作研究
7. Pooled association genome scanning for alcohol dependence using 104 268 SNPs: validation and use to identify alcoholism vulnerability loci in unrelated individuals from the collaborative study on the genetics of alcoholism [O] . Catherine Johnson, Tomas Drgon, Qing-rong Liu, 2006

机译：使用104 268个sNp汇总关联基因组扫描酒精依赖：通过酗酒遗传学的合作研究验证并用于识别无关个体中的酒精中毒脆弱性位点

Re-analysis of Collaborative Study on the Genetics of Alcoholism pedigrees suggests the presence of loci influencing novelty-seeking near D12S391 and D17S1299.

摘要

著录项

相似文献

相关主题

期刊订阅