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首页> 外文期刊>Psychiatric genetics >A variant in the reelin gene increases the risk of schizophrenia and schizoaffective disorder but not bipolar disorder.
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A variant in the reelin gene increases the risk of schizophrenia and schizoaffective disorder but not bipolar disorder.

机译：reelin基因的变异会增加精神分裂症和分裂情感障碍的风险，但不会增加躁郁症的风险。

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Schizophrenia (SZ), schizoaffective disorder (SA), and bipolar disorder (BD) are among the most common severe psychiatric disorders. Although the diseases are defined as distinct by the Diagnostic and Statistical Manual of Mental Disorder fourth edition, they share noticeable behavioral similarities. On the basis of the pedigree observations, it has been argued for a possible shared genetic background, as articulated by Silberschmidt and Sponheim (2008) in their introduction. Consequently, it seems of value and importance to test genetic associations discovered for SZ, also in BD and SA samples. We have recently conducted a whole genome association study to identify genes involved in SZ, where the GG genotype of the rs7341475 single-nucleotide polymorphism in the RELN gene was found to increase the risk to develop SZ in women only (P=8.8 x 10~(-7)) (Shifman et al., 2008). In this study, we now investigate the genotypic distribution of this variant among SA and BD patients, separately in men and women.
机译：精神分裂症（SZ），精神分裂症（SA）和躁郁症（BD）是最常见的严重精神病。尽管《精神疾病诊断和统计手册》第四版将这些疾病定义为不同的疾病，但它们具有明显的行为相似性。根据系谱观察，有人提出可能存在共享的遗传背景，如Silberschmidt和Sponheim（2008）在介绍中所述。因此，测试在BD和SA样本中发现的SZ遗传关联似乎具有价值和重要性。我们最近进行了一项全基因组关联研究，以鉴定参与SZ的基因，其中发现RELN基因中rs7341475单核苷酸多态性的GG基因型增加了仅女性发展SZ的风险（P = 8.8 x 10〜 （-7））（Shifman et al。，2008）。在这项研究中，我们现在分别在男性和女性中调查SA和BD患者之间该变体的基因型分布。

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