High activity of Monoamine oxidase A is associated with externalizing behaviour in maltreated and nonmaltreated adoptees.

van der Vegt EJ; Oostra BA; Arias Vasquez A

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High activity of Monoamine oxidase A is associated with externalizing behaviour in maltreated and nonmaltreated adoptees.

机译：单胺氧化酶A的高活性与受虐待和未经虐待的收养者的外在化行为有关。

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Individual differences in a functional polymorphism of the promoter of the Monoamine oxidase A (MAO-A) gene might partly explain the increased vulnerability of maltreated children for externalizing behaviour. A sample of 239 internationally adopted boys was studied. Adoptive parents provided the information about abuse and neglect before the adoption and rated externalizing behaviour of their adopted children, using the Child Behaviour Checklist. MAO-A alleles were classified in high and low activity. We found that individuals with high MAO-A activity had more externalizing behaviour than those with low MAO-A activity. No modifying effect of MAO-A on the relationship between early maltreatment on externalizing behaviour was observed. Our results suggest that in severely maltreated children, high MAO-A activity may not protect against the effects of maltreatment but may convey an increased risk for externalizing behaviour.

机译：单胺氧化酶A（MAO-A）基因启动子功能多态性的个体差异可能部分解释了虐待儿童对外部行为的脆弱性增加。研究了239名国际收养男孩的样本。收养父母在收养之前提供了有关虐待和忽视的信息，并使用“儿童行为清单”对收养孩子的外在行为进行了评分。将MAO-A等位基因分为高活性和低活性。我们发现，具有较高MAO-A活性的个体比具有较低MAO-A活性的个体具有更多的外在行为。没有观察到MAO-A对早期虐待与外在行为之间关系的修饰作用。我们的结果表明，在受到严重虐待的儿童中，较高的MAO-A活性可能无法抵御虐待的影响，但可能会增加外部行为的风险。

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《Psychiatric genetics》 |2009年第4期|共3页
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van der Vegt EJ; Oostra BA; Arias Vasquez A;
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1. High activity of Monoamine oxidase A is associated with externalizing behaviour in maltreated and nonmaltreated adoptees. [J] . van der Vegt EJ, Oostra BA, Arias Vasquez A Psychiatric genetics . 2009,第4期

机译：单胺氧化酶A的高活性与受虐待和未经虐待的收养者的外在化行为有关。
2. The monoamine oxidase A (MAO-A) gene, family function and maltreatment as predictors of destructive behaviour during male adolescent alcohol consumption. [J] . Nilsson KW, Sjoberg RL, Wargelius HL, Addiction . 2007,第3期

机译：单胺氧化酶A（MAO-A）基因，家族功能和虐待是男性青少年饮酒期间破坏行为的预测指标。
3. The interaction between monoamine oxidase A (MAOA) and childhood maltreatment as a predictor of personality pathology in females: Emotional reactivity as a potential mediating mechanism – ERRATUM [J] . Amy L.Byrd, Stephen B.Manuck, Samuel W.Hawes, Development and psychopathology . 2019,第1期

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4. The role of monoamine oxidase A, MAOA, in the aetiology of antisocial behaviour: the importance of gene-environment interactions [C] . Ian W. Crai Symposium on Molecular Mechanisms Influencing Aggressive Behaviours . 2005

机译：单胺氧化酶A，Maoa在反社会行为的疾病中的作用：基因环境相互作用的重要性
5. Expression and functional characterization of monoamine oxidase from the zebrafish (Danio rerio): Comparisons with human monoamine oxidases A and B. [D] . Kacar, Betul. 2009

机译：斑马鱼（Danio rerio）单胺氧化酶的表达和功能表征：与人单胺氧化酶A和B的比较。
6. Behavioural hyperactivity in rats treated with selective monoamine oxidase inhibitors and LM 5008 a selective 5-hydroxytryptamine uptake blocker. [O] . R. Ashkenazi, J. P. Finberg, M. B. Youdim 1983

机译：用选择性单胺氧化酶抑制剂和LM 5008（选择性5-羟色胺摄取阻滞剂）治疗的大鼠的行为亢进。
7. PREDICTING DRUNK DRIVING: CONTRIBUTION OF ALCOHOL USE AND RELATED PROBLEMS, TRAFFIC BEHAVIOUR, PERSONALITY AND PLATELET MONOAMINE OXIDASE (MAO) ACTIVITY [O] . Diva Eensoo, Marika Paaver, Maarike Harro, 2005

机译：预测驾驶驾驶：酒精使用的贡献和相关问题，交通行为，人格和血小板单胺氧化酶（maO）活动

High activity of Monoamine oxidase A is associated with externalizing behaviour in maltreated and nonmaltreated adoptees.

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