• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Psychiatric genetics >Association study of serotonergic gene variants with antipsychotic-induced adverse reactions.
【24h】

Association study of serotonergic gene variants with antipsychotic-induced adverse reactions.

机译：血清素能基因变异与抗精神病药引起的不良反应的关联研究。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

INTRODUCTION: The products of the serotonin receptor genes are important targets for conventional and atypical antipsychotics, and may be relevant for antipsychotic activity and associated adverse reactions. It has been shown that the high potency at 5-HT2 receptors may also be associated with the production of moderate extrapyramidal side effects (EPS). In addition, serotonin neurotransmitter systems in the central nervous system play an important role in eating behaviours, and are involved in the symptomatology related to the metabolic syndrome, including obesity, diabetes and hyperlipidemia. MATERIALS AND METHODS: This study was designed to investigate the hypothesis that serotonin pathway genes play a part in mediating antipsychotic-induced adverse reactions, including EPS, tardive dyskinesia, obesity and diabetes. Polymorphisms in the 5-HT2A (102 (T/C), His452Tyr), 5-HT2C (Cys23Ser, -759 (C/T), -995 (G/A), TPH2 (-366 (C/T), -8933 (A/G) and 5-HTT (LPR, -15370 (A/G)) genes were investigated in a cohort of 427 US Caucasian patients undergoing antipsychotic treatment, using automated genotyping techniques. RESULTS: 5-HTT (LPR) and 5-HT2A (102 (T/C) polymorphisms were found to be associated with BMI (P=0.05 and 0.005, respectively). The genotype distribution of the TPH2-366 (T/C) polymorphism was found to be significantly associated with the presence of diabetes (P=0.01). A trend towards an association (P=0.07) between the 5-HT2C Cys23Ser polymorphism and tardive dyskinesia was found when age, duration of treatment, dose and sex were considered. Genotype distributions of the 5-HT2C -995 (G/A), 5-HT2C -759 (C/T) and 5-HT2A His452Tyr polymorphisms differed among patients presenting EPS and those without (P=0.08, 0.06 and 0.08, respectively). No other statistically significant associations were observed. CONCLUSION: Serotonergic polymorphism may play a moderate role in the development of side effects associated with antipsychotic treatment.
机译：简介：血清素受体基因的产物是常规和非典型抗精神病药的重要靶标，可能与抗精神病药的活性及相关的不良反应有关。已经显示出对5-HT 2受体的高效力也可能与中等锥体束外副作用（EPS）的产生有关。此外，中枢神经系统中的5-羟色胺神经递质系统在饮食行为中起重要作用，并参与与代谢综合征相关的症状，包括肥胖，糖尿病和高脂血症。材料与方法：本研究旨在调查5-羟色胺途径基因在介导抗精神病药物引起的不良反应（包括EPS，迟发性运动障碍，肥胖症和糖尿病）中起作用的假设。 5-HT2A（102（T / C），His452Tyr），5-HT2C（Cys23Ser，-759（C / T），-995（G / A），TPH2（-366（C / T），-使用自动基因分型技术，在427名接受抗精神病治疗的美国白人患者中，研究了8933（A / G）和5-HTT（LPR，-15370（A / G））基因。发现5-HT2A（102（T / C）多态性与BMI相关（分别为P = 0.05和0.005），TPH2-366（T / C）多态性的基因型分布与BMI显着相关。考虑到年龄，治疗时间，剂量和性别，发现5-HT2C Cys23Ser多态性与迟发性运动障碍之间有关联（P = 0.01）趋势（P = 0.07）; 5-基因的分布HT2C -995（G / A），5-HT2C -759（C / T）和5-HT2A His452Tyr多态性在有EPS的患者和无EPS的患者之间有所不同（分别为P = 0.08、0.06和0.08）。被观察。结论：血清素能多态性可能在抗精神病药物治疗相关副作用的发生中起中等作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号