Replication of an association of a common variant in the Reelin gene (RELN) with schizophrenia in Ashkenazi Jewish women.

Liu Y; Chen PL; McGrath J; Wolyniec P; Fallin D; Nestadt G; Liang KY; Pulver A; Valle D; Avramopoulos D

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Replication of an association of a common variant in the Reelin gene (RELN) with schizophrenia in Ashkenazi Jewish women.

机译：阿什肯纳兹犹太妇女中Reelin基因（RELN）常见变异与精神分裂症的关联复制。

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A single nucleotide polymorphism (rs7341475) in RELN has recently been shown to be associated with schizophrenia (SZ) in an Ashkenazi Jewish (AJ) case--control study specifically in women by Shifman et al. We have replicated this association in women in another large independent Ashkenazi Jewish collection (721 cases, 259 female; 1455 controls, 834 female) and confirmed that it applies to both SZ and schizoaffective disorder. Furthermore, we explore the effects of this polymorphism through quantitative trait loci analysis of nine SZ related factors providing information on sex-specific genotype--phenotype correlations.

机译：Shifman等人最近在一个Ashkenazi犹太人（AJ）病例对照研究中显示，RELN中的单核苷酸多态性（rs7341475）与精神分裂症（SZ）有关。我们已在另一个大型独立的阿什肯纳兹犹太人收藏中（721例，女性259; 1455对照，834女性）在女性中复制了这种关联，并确认它适用于SZ和分裂情感障碍。此外，我们通过对9个SZ相关因子进行定量性状基因座分析来探索这种多态性的影响，从而提供有关性别特异性基因型-表型相关性的信息。

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《Psychiatric genetics》 |2010年第4期|共3页
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Liu Y; Chen PL; McGrath J; Wolyniec P; Fallin D; Nestadt G; Liang KY; Pulver A; Valle D; Avramopoulos D;
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正文语种 eng
中图分类医学遗传学;
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1. Replication of an association of a common variant in the Reelin gene (RELN) with schizophrenia in Ashkenazi Jewish women. [J] . Liu Y, Chen PL, McGrath J, Psychiatric genetics . 2010,第4期

机译：阿什肯纳兹犹太妇女中Reelin基因（RELN）常见变异与精神分裂症的关联复制。
2. Association study of the reelin (RELN) gene with Chinese Va schizophrenia [J] . YangX.B., KangC., LiuH., Psychiatric genetics . 2013,第3期

机译：reelin（RELN）基因与中国精神分裂症的关联研究
3. Genome-Wide Association Identifies a Common Variant in the Reelin Gene That Increases the Risk of Schizophrenia Only in Women [J] . Sagiv Shifman, Martina Johannesson, Michal Bronstein, PLoS Genetics . 2008,第2期

机译：全基因组协会鉴定了Reelin基因的常见变体，该变体仅在女性中增加了精神分裂症的风险
4. ASSOCIATION ANALYSIS BETWEEN RELN GENE AND AUTISM BASED ON MICROARRAY METHOD [C] . Yao Yang, Wanqiong Qiao, Lu Cheng, 第四届国际后基因组生命科学技术学术论坛 . 2006

机译：基于微阵列方法的相关基因与自闭症的关联分析
5. A decision analysis of testing for breast-ovarian cancer susceptibility genes in women of Ashkenazi Jewish descent. [D] . Miller, Lesley-Ann Natasha. 2000

机译：Ashkenazi犹太血统女性乳腺癌-卵巢癌易感基因测试的决策分析。
6. Replication of an association of a common variant in the Reelin gene (RELN) with schizophrenia in Ashkenazi Jewish women [O] . Yaping Liu, Pei-Lung Chen, John McGrath, -1

机译：复制Reelin基因（Reln）中常见变体与精神分裂症的常用变体与阿什蒽齐犹太女性的共同变体
7. Replication of an association of a common variant in the Reelin gene (RELN) with schizophrenia in Ashkenazi Jewish women [O] . Yaping Liu, Pei-Lung Chen, John McGrath, 2010

机译：复制Reelin基因（Reln）中常见变体与精神分裂症的常用变体与阿什蒽齐犹太女性的共同变体
8. Decision-Making Regarding Prophylactic Mastectomy and Oophorectomy in Ashkenazi Jewish Women Seeking Genetic Testing for BRCA1/BRCA2 Mutations [R] . Hurley, K. , Redd, W. 2001

机译：关于德系犹太妇女预防性乳房切除术和卵巢切除术的决策寻求BRCa1 / BRCa2突变的基因检测

Replication of an association of a common variant in the Reelin gene (RELN) with schizophrenia in Ashkenazi Jewish women.

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