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首页> 外文期刊>Psychiatric genetics >Catechol-O-methyltransferase modulation of cortisol secretion in psychiatrically at-risk and healthy adolescents.
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Catechol-O-methyltransferase modulation of cortisol secretion in psychiatrically at-risk and healthy adolescents.

机译：精神病高危青少年和健康青少年中邻苯二酚-O-甲基转移酶对皮质醇分泌的调节。

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OBJECTIVE: Recent research implicates the catechol-O-methyltransferase (COMT) ValMet polymorphism in stress sensitivity, through modulation of hypothalamic-pituitary-adrenal (HPA) function. In healthy samples, Met homozygosity has been associated with greater HPA activity (i.e., cortisol) and stress sensitivity, though findings are mixed among clinical samples. To date, there are no reports examining baseline or longitudinal changes in HPA activity as a function of COMT genotype in youth. This study tested the hypothesis that COMT genotype would be associated with cortisol secretion in normal and at-risk adolescents; specifically, that COMT genotype would be linked in a dose-response manner such that Met homozygotes would have the highest salivary cortisol levels, followed by heterozygotes, then Val homozygotes. In addition, this study examined the relation of COMT genotype with longitudinal changes in cortisol. METHODS: This study examined the association of COMT with salivary cortisol across a 1-year period in healthy and at-risk adolescents with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision Axis II diagnoses. RESULTS: Results indicated higher cortisol levels for Met homozygotes (compared with heterozygotes and Val homozygotes) at the 1-year follow-up, and increased mean cortisol levels across a 1-year period among Met carriers, suggesting that COMT associates with differences in cortisol secretion during adolescence. CONCLUSION: Findings are discussed with respect to COMT genotype as a potential genetic indicator of psychiatric risk that modulates developmental changes in HPA activity.
机译：目的：最近的研究表明，通过调节下丘脑-垂体-肾上腺（HPA）功能，儿茶酚-O-甲基转移酶（COMT）ValMet多态性可引起应激敏感性。在健康样本中，尽管临床样本之间的发现混合，但Met纯合性与更高的HPA活性（即皮质醇）和应激敏感性相关。迄今为止，还没有报告检查青年时期HPA活动的基线或纵向变化与COMT基因型的关系。这项研究检验了以下假设：在正常和处于危险中的青少年中，COMT基因型与皮质醇的分泌有关。具体来说，该COMT基因型将以剂量反应方式关联，从而使Met纯合子的唾液皮质醇水平最高，其次是杂合子，然后是Val纯合子。此外，这项研究检查了COMT基因型与皮质醇的纵向变化之间的关系。方法：本研究通过《精神疾病诊断和统计手册》（第四版，文本修订第II轴诊断）检查了健康和高危青少年在1年内COMT与唾液皮质醇的相关性。结果：结果表明，在1年随访中，Met纯合子（与杂合子和Val纯合子相比）的皮质醇水平较高，并且在Met携带者的1年期间，平均皮质醇水平增加，这表明COMT与皮质醇的差异相关在青春期分泌。结论：讨论了有关COMT基因型的发现，该基因型是调节HPA活性发展变化的精神病风险的潜在遗传指标。

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