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首页> 外文期刊>Psychiatric genetics >The dopamine D2 receptor gene and depressive and anxious symptoms in childhood: associations and evidence for gene-environment correlation and gene-environment interaction.
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The dopamine D2 receptor gene and depressive and anxious symptoms in childhood: associations and evidence for gene-environment correlation and gene-environment interaction.

机译：多巴胺D2受体基因与儿童抑郁和焦虑症状：基因与环境之间的关联和证据以及基因与环境之间的相互作用。

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OBJECTIVES: Research implicates the A1 allele of the dopamine D2 receptor gene (DRD2) Taq1A polymorphism in the development of depression and anxiety. Furthermore, recent papers suggest that children with A1 allele of this gene may receive less positive parenting, and that the effects of this gene on child symptoms may be moderated by parenting. We sought to replicate and extend these findings using behavioral measures in a nonclinical sample of young children. METHODS: In a sample of 473 preschool-aged children and their mothers, structured clinical interview measures and maternal reports of child symptoms were collected, and standardized observations of parent-child interactions were conducted. RESULTS: An association was detected between the DRD2 A1 allele and symptoms of depression and anxiety indexed using interview and parent report methods. As found in previous reports, children with the DRD2 A1 allele received less supportive parenting and displayed higher levels of negative emotionality during parent-child interactions. Tests of mediation and moderation were conducted. CONCLUSION: We found associations between the DRD2 A1 allele and early-emerging anxious and depressive symptoms in a community sample of preschool-aged children, and evidence of a gene-environment correlation and moderation of the main effect of child genotype on child symptoms by parenting.
机译：目的：研究表明多巴胺D2受体基因（DRD2）Taq1A多态性的A1等位基因与抑郁症和焦虑症的发生有关。此外，最近的论文表明，具有该基因的A1等位基因的儿童可能没有那么积极的父母教养，而且该基因对儿童症状的影响可以通过父母教养得到缓解。我们试图在非临床儿童样本中使用行为测量来复制和扩展这些发现。方法：在473名学龄前儿童及其母亲的样本中，收集了结构化的临床访谈方法和有关儿童症状的母亲报告，并对父母与孩子之间的互动进行了标准化观察。结果：在DRD2 A1等位基因与抑郁和焦虑症状之间的关联被发现，采用访谈和父母报告方法进行索引。如以前的报告所述，患有DRD2 A1等位基因的儿童在亲子互动过程中获得较少的支持性父母养育，并表现出较高水平的负面情绪。进行了调解和节制测试。结论：我们在学龄前儿童的社区样本中发现了DRD2 A1等位基因与早期出现的焦虑和抑郁症状之间的关联，并证明了基因环境相关性以及父母通过儿童基因型对儿童症状的主要影响的调节作用的证据。

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