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首页> 外文期刊>Progress in brain research >Competition in neurite outgrowth and the development of nerve connections.
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Competition in neurite outgrowth and the development of nerve connections.

机译：神经突生长的竞争和神经连接的发展。

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摘要

During the development of the nervous system, neurons form their characteristic morphologies and become assembled into synaptically connected networks. In both neuronal morphogenesis and the development of nerve connections, competition plays an important role. Although the notion of competition is commonly used in neurobiology, there is little understanding of the nature of the competitive process and the underlying molecular and cellular mechanisms. In this chapter, we review a model of competition between outgrowing neurites, as well as various models of competition that have been proposed for the refinement of connections that takes place in the development of the neuromuscular and visual systems. We describe in detail a model that links competition in the development of nerve connections with the underlying actions and biochemistry of neurotrophic factors.
机译：在神经系统发育过程中，神经元形成其特征形态并组装成突触连接的网络。在神经元形态发生和神经连接的发展中，竞争起着重要的作用。尽管竞争的概念在神经生物学中很常用，但是对竞争过程的本质以及潜在的分子和细胞机制知之甚少。在本章中，我们回顾了向外突起的神经突之间的竞争模型，以及为完善神经肌肉和视觉系统发展中的联系而提出的各种竞争模型。我们详细描述了一个模型，该模型将神经连接发育中的竞争与神经营养因子的潜在作用和生物化学联系起来。

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