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首页> 外文期刊>Progress in brain research >A SPECT study of language and brain reorganization three years after pediatric brain injury.
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A SPECT study of language and brain reorganization three years after pediatric brain injury.

机译：小儿脑损伤三年后语言和大脑重组的SPECT研究。

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Using single photon emission computed tomography (SPECT), we investigated brain plasticity in children 3 years after sustaining a severe traumatic brain injury (TBI). First, we assessed brain perfusion patterns (i.e., the extent of brain blood flow to regions of the brain) at rest in eight children who suffered severe TBI as compared to perfusion patterns in eight normally developing children. Second, we examined differences in perfusion between children with severe TBI who showed good versus poor recovery in complex discourse skills. Specifically, the children were asked to produce and abstract core meaning for two stories in the form of a lesson. Inconsistent with our predictions, children with severe TBI showed areas of increased perfusion as compared to normally developing controls. Adult studies have shown the reverse pattern with TBI associated with reduced perfusion. With regard to the second aim and consistent with previously identified brain-discourse relations, we found a strong positive association between perfusion in right frontal regions and discourse abstraction abilities, with higher perfusion linked to better discourse outcomes and lower perfusion linked to poorer discourse outcomes. Furthermore, brain-discourse patterns of increased perfusion in left frontal regions were associated with lower discourse abstraction ability. The results are discussed in terms of how brain changes may represent adaptive and maladaptive plasticity. The findings offer direction for future studies of brain plasticity in response to neurocognitive treatments.
机译：使用单光子发射计算机断层扫描（SPECT），我们调查了严重外伤性脑损伤（TBI）3年后儿童的大脑可塑性。首先，我们评估了八名患有严重TBI的儿童在静息时的脑灌注模式（即脑血流到大脑区域的程度），而八名正常发育的儿童则处于灌注模式。其次，我们研究了重型TBI儿童在复杂话语能力恢复方面表现良好与不良之间的灌注差异。具体来说，要求孩子们以一堂课的形式为两个故事产生和抽象核心含义。与我们的预测不一致，患有重度TBI的儿童与正常发育的对照组相比显示出增加的灌注区域。成人研究表明，TBI的逆向模式与灌注减少有关。关于第二个目标，并与先前确定的脑-话语关系相一致，我们发现右额叶区域的灌注与话语抽象能力之间具有很强的正相关性，其中较高的灌注与较好的话语结果相关，而较低的灌注与较差的话语结果相关。此外，左额叶区域灌注增加的大脑话语模式与话语抽象能力较低有关。根据大脑变化如何代表适应性和适应不良的可塑性来讨论结果。这些发现为未来对神经认知治疗的大脑可塑性研究提供了方向。

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