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首页> 外文期刊>Progress in brain research >Staying awake for dinner: hypothalamic integration of sleep, feeding, and circadian rhythms.
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Staying awake for dinner: hypothalamic integration of sleep, feeding, and circadian rhythms.

机译:保持清醒的晚餐时间:下丘脑整合睡眠,进食和昼夜节律。

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摘要

Daily patterns of sleep and wakefulness are inextricably linked to the regulation of feeding and energy metabolism. Both are affected by homeostatic as well as circadian drives, and both are tightly linked to thermoregulation. In this chapter, we review the basic drain circuitry that regulates sleep and wakefulness, including the flip-flop switch relationship of the arousal system and the ventrolateral preoptic sleep-promoting neurons. We then examine the role of the orexin/hypocretin neurons, which stabilize the switch while driving both wakefulness and foraging for food. We also review the role of the subparaventricular nucleus and the dorsomedial nucleus of the hypothalamus in circadian integration and modulation of both feeding and wake-sleep patterns.
机译:日常睡眠和清醒模式与喂养和能量代谢的调节有着千丝万缕的联系。两者均受稳态和昼夜节律驱动的影响,并且两者均与温度调节紧密相关。在本章中,我们回顾了调节睡眠和清醒的基本消耗电路,包括唤醒系统和腹侧前视神经促进神经元的触发器开关关系。然后,我们检查了orexin / hypocretin神经元的作用,它们在驱动觉醒和觅食的同时稳定开关。我们还审查了下丘脑室旁核和背侧核在昼夜节律的整合和喂养和唤醒-睡眠模式的调节中的作用。

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