Chronobiology in aortic diseases - 'is this really a random Phenomenon?'

ManfrediniR.; FabbianF.; ManfrediniF.; SalmiR.; GalleraniM.; BossoneE.

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Chronobiology in aortic diseases - 'is this really a random Phenomenon?'

机译：主动脉疾病的时间生物学-“这真的是随机现象吗？”

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Although acute aortic rupture or dissection is relatively uncommon, it ranks in third position among necropsy-confirmed causes of out-of-hospital sudden death in the general population. Similar to other acute cardiovascular events (e.g., acute myocardial infarction, sudden death, stroke, and pulmonary embolism) there is a growing body of evidence regarding temporal patterns in onset, characterized by circadian, seasonal and weekly variations for aortic aneurysms. On one hand, it is possible that these cardiovascular diseases share common underlying pathophysiologic mechanisms, e.g., increase in blood pressure, heart rate, sympathetic activity, basal vascular tone, vasoconstrictive hormones, and prothrombotic tendency.On the other hand, the possibility exists that the connecting link is an internal disruption (dyssynchrony) of some molecular mechanisms intrinsic to the peripheral biological clock (that of cardiomyocyte is the most widely investigated). Such disruption may contribute to cardiovascular disease and biological rhythms - an intriguing hypothesis for future research.

机译：尽管急性主动脉破裂或夹层比较少见，但在一般人群经尸检确认的院外猝死原因中，它排在第三位。与其他急性心血管事件（例如急性心肌梗塞，猝死，中风和肺栓塞）相似，关于发作时间模式的证据也越来越多，其特征是主动脉瘤的昼夜节律，季节性和每周变化。一方面，这些心血管疾病可能具有共同的潜在病理生理机制，例如血压升高，心律加快，交感神经活动，基础血管紧张，血管收缩激素和血栓形成倾向。另一方面，存在以下可能性：连接是外围生物钟固有的某些分子机制的内部破坏（不同步）（研究最广泛的是心肌细胞的内部机制）。这种破坏可能会导致心血管疾病和生物节律-未来研究的一个有趣的假设。

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《Progress in Cardiovascular Diseases》 |2013年第1期|共9页
作者
ManfrediniR.; FabbianF.; ManfrediniF.; SalmiR.; GalleraniM.; BossoneE.;
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正文语种 eng
中图分类心脏、血管（循环系）疾病;
关键词
Aortic aneurysm; Aortic aneurysm; abdominal; Aortic aneurysm; thoracic; Aortic rupture; Chronobiology; Circadian rhythm; Seasons;

机译：主动脉瘤;主动脉瘤;腹部;主动脉瘤;胸廓;主动脉破裂;计时生物学;昼夜节律;季节;

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1. Chronobiology in aortic diseases - "is this really a random Phenomenon?" [J] . ManfrediniR., FabbianF., ManfrediniF., Progress in Cardiovascular Diseases . 2013,第1期

机译：主动脉疾病的时间生物学-“这真的是随机现象吗？”
2. Chronobiology of Acute Aortic Dissection in the Marfan Syndrome (from the National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions and the International Registry of Acute Aortic Dissection) [J] . Siddiqi Hasan K., Luminais Steven N., Montgomery Dan, The American Journal of Cardiology . 2017,第5期

机译：玛司综合征中急性主动脉夹层的年代学（来自国家注册机构的转基因胸主动脉瘤和心血管条件以及急性主动脉夹层的国际登记号）
3. Reduction of "no-reflow" phenomenon by intra-aortic balloon counterpulsation in a randomized magnetic resonance imaging experimental study. [J] . Amado LC, Kraitchman DL, Gerber BL, Journal of the American College of Cardiology . 2004,第7期

机译：在随机磁共振成像实验研究中，通过主动脉内球囊反搏减少“无回流”现象。
4. Statins in Calcific Aortic Valve Disease: From Bench to BedsideDesigning Clinical Trials in Aortic Valve Disease: From Bench to Bedside [C] . Rajamannan Nalini M. Moura Luis M. World Congress on Heart Disese-International Academy of Cardiology Annual Scientific Session 2010 . 2010

机译：钙化主动脉瓣病的他汀类药物：从长凳到主动脉瓣病的临床试验：从长凳到床边
5. Combined Effects of Acute Prolonged Sitting and Mental Stress on Aortic Stiffness in Middle-Aged Adults: A Randomized Crossover Trial [D] . Diana, Jake Christopher. 2020

机译：急性长期坐着和精神胁迫对中年成人主动脉僵硬的综合影响：随机交叉试验
6. The Chronobiology of Stanford Type A Aortic Dissections [O] . Abe DeAnda Jr, Eugene A. Grossi, Leora B. Balsam, 2015

机译：斯坦福大学A型主动脉夹层的年代生物学
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Chronobiology in aortic diseases - 'is this really a random Phenomenon?'

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