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首页> 外文期刊>Prostaglandins and Other Lipid Mediators >Uterine autonomic nerve innervation plays a crucial role in regulating rat uterine mast cell functions during embryo implantation
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Uterine autonomic nerve innervation plays a crucial role in regulating rat uterine mast cell functions during embryo implantation

机译：子宫自主神经支配在胚胎着床过程中调节大鼠子宫肥大细胞功能中起关键作用

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摘要

To explore the potential mechanism of how uterine innervations would affect the uterine mast cell (MC) population and functions during the periimplantation. We herein first examined the consequence of uterine neurectomy on embryo implantation events. We observed that amputation of autonomic nerves innervating the uterus led to on-time implantation failure in rats. Exploiting MC culture and ELISA approaches, we then further analyzed the effect of neurectomy on cellular histamine levels and its release from uterine MCs, to elucidate the relation of the autonomic nerves and local cellular immunity in the uterine during early pregnancy. We observed that disconnection of autonomic nerve innervation significantly increased the population of uterine MCs. Most interestingly, these increased number of uterine MCs in neuroectomized rats contained a much reduced cellular level of histamine. Our subsequent challenge experiments revealed that uterine MCs in nerve amputated rats exhibited enhanced histamine releasing rate in response to substance P and antiIgE, suggesting loss of nerve innervation in the uterus not only increases the population of uterine MCs, but also facilitates the release of histamine from MCs, thus subsequently interfere with the normal implantation process. Collectively, our findings provide a new line of evidence supporting the concept that immune-neuro-endocrine network plays important role during pregnancy establishment and maintenance.
机译：为了探讨子宫神经支配将如何影响子宫肥大细胞（MC）的人口和功能在植入过程中的潜在机制。我们在本文中首先检查了子宫神经切除术对胚胎着床事件的影响。我们观察到截肢支配子宫的自主神经导致大鼠准时植入失败。利用MC培养和ELISA方法，我们进一步分析了神经切除术对细胞组胺水平及其从子宫MCs释放的影响，以阐明妊娠早期子宫中自主神经与局部细胞免疫的关系。我们观察到自主神经支配的断开显着增加了子宫MC的数量。最有趣的是，这些在神经切除的大鼠中增加的子宫MC含量大大降低了组胺的细胞水平。我们随后的挑战实验表明，截肢神经大鼠的子宫MCs对P物质和抗IgE的反应显示出增强的组胺释放速率，这表明子宫内神经支配力的丧失不仅增加了子宫MCs的数量，而且还促进了组织胺从子宫中的释放。因此，MC随后会干扰正常的植入过程。总的来说，我们的发现提供了新的证据，支持免疫神经内分泌网络在怀孕建立和维持过程中发挥重要作用的观点。

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