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首页> 外文期刊>Progress in brain research >Chondroitin sulphate proteoglycans in the CNS injury response.
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Chondroitin sulphate proteoglycans in the CNS injury response.

机译：硫酸软骨素蛋白聚糖对中枢神经系统的损伤反应。

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As the preceding discussion has demonstrated, experimental data now indicate that the expression of a number of different CSPGs is increased following CNS injury. The hyalectans neurocan, versican and [figure: see text] brevican, plus NG2 and phosphacan are upregulated following injury and all have been shown to exhibit inhibitory effects on neurite outgrowth in vitro. It is likely therefore that the increased expression of these molecules contributes to the non-permissive nature of the glial scar. The relative contributions of individual molecules remain, however, to be determined. It is important to remember also that not only does the glial scar contain many different inhibitory molecules, but that these are the products of a number of different cells, including not just astrocytes, but also oligodendrocyte progenitor and meningeal cells. It is arguable that the latter two cell types make a greater contribution than astrocytes to the inhibitory environment of the injured CNS. Recently, attempts havebeen made to alter the CSPG component of the glial scar in the hope that this will facilitate improved axonal regeneration. Three studies (Bradbury et al., 2002; Yick et al., 2000; Moon et al., 2001) have reported an improved regenerative response following treatment of the injured CNS with chondroitinase ABC. CSPGs represent a significant source of inhibition within the injured CNS; these studies indicate that successful CNS regeneration may be brought about by interventions which target these molecules and/or the cells which produce them.
机译：如前面的讨论所示，实验数据表明，CNS损伤后许多不同CSPG的表达增加。透明质酸神经聚糖，versican和brevican以及NG2和phosphacan在损伤后均被上调，并且均显示出对神经突生长的抑制作用。因此，这些分子表达的增加可能有助于神经胶质瘢痕的非许可性质。但是，各个分子的相对贡献尚待确定。同样重要的是要记住，神经胶质瘢痕不仅包含许多不同的抑制分子，而且这些分子是许多不同细胞的产物，不仅包括星形胶质细胞，还包括少突胶质细胞祖细胞和脑膜细胞。可以争论的是，后两种细胞类型比星形胶质细胞对受伤的中枢神经系统的抑制环境的贡献更大。最近，已经尝试改变神经胶质瘢痕的CSPG成分，希望这将有助于改善的轴突再生。三项研究（Bradbury等，2002; Yick等，2000; Moon等，2001）报告了用软骨素酶ABC治疗受损的中枢神经系统后，再生反应得到改善。 CSPGs是受伤的中枢神经系统抑制作用的重要来源。这些研究表明成功的中枢神经系统再生可以通过针对这些分子和/或产生它们的细胞的干预来实现。

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