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首页> 外文期刊>Progress in brain research >Progressive behavioral changes in children with epilepsy.
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Progressive behavioral changes in children with epilepsy.

机译：癫痫患儿的行为习惯逐渐改变。

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Children with epilepsy are known to have high rates of mental health problems. The role of seizures in the development of these problems is not known primarily because of difficulties in separating the effects of seizures from the three other potential causal factors: (a) poor child and family response to the condition, (b) side effects of antiepileptic medication, and (c) neurological dysfunction that causes both the seizures and the behavioral problems. Although cross-sectional studies focusing on children with chronic epilepsy show associations between behavior problems and each of these causal factors, it is not possible to isolate the effects of any one causal factor using this design. A stronger approach is to conduct prospective studies of children with new-onset seizures. Recent research on children with new-onset seizures suggests that side effects of antiepileptic medication and poor child and family response do not play major roles in the development of behavior problems. Results from a prospective study in children with new-onset seizures show an association between seizures and behavior problems. Separating effects of seizures from effects of neurological dysfunction on behavior problems, however, will be difficult even in prospective studies of children with new-onset seizures. Transient cognitive impairment (TCI) from interictal epileptiform discharges is proposed as an alternative explanation for behavior problems.
机译：已知患有癫痫病的儿童有很高的精神健康问题。癫痫在这些问题发生中的作用尚不清楚，主要是因为难以将癫痫发作的影响与其他三个潜在的因果关系分开：（a）儿童和家庭对病情的不良反应，（b）抗癫痫药的副作用药物治疗;以及（c）引起癫痫发作和行为问题的神经功能障碍。尽管针对慢性癫痫儿童的横断面研究表明，行为问题与这些因果因素之间存在关联，但使用这种设计不可能隔离任何一种因果因素的影响。一种更有效的方法是对新发癫痫发作的儿童进行前瞻性研究。对新发癫痫发作的儿童的最新研究表明，抗癫痫药的副作用以及不良的儿童和家庭反应在行为问题的发展中不发挥主要作用。对新发癫痫发作的儿童进行的一项前瞻性研究结果表明，癫痫发作与行为问题之间存在关联。然而，即使在对新发癫痫发作的儿童进行前瞻性研究中，将癫痫发作的影响与神经功能障碍对行为问题的影响分开也是困难的。提出了间质癫痫样放电的短暂认知障碍（TCI）作为行为问题的另一种解释。

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