Effects of brief seizures during development.

Velisek L; Moshe SL

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Effects of brief seizures during development.

机译：发育过程中短暂发作的影响。

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The effects of brief seizures during development depend on multiple factors such as underlying brain pathology, specific age of occurrence and frequency. Studies in rats are frequently used to determine the consequences of seizures in the developing brain. The shorter prepubertal development and life span of the rat compared to humans may suggest that brief seizures in the rat are not necessarily equivalent to brief seizures in humans. Nevertheless, there is substantial evidence that in the rat, the consequences of seizures are age-dependent. The immature brain is relatively resistant to morphological damage, especially in the hippocampus, and functional changes as measured by electrophysiology and behavior. Developmental kindling can be used as a model to study brief seizures early in life. Kindling permanently alters the brain so that rats stimulated again in adulthood require only few kindling stimuli for fully kindled seizures to occur although there are no apparent morphological and functional changes in the hippocampus resulting from kindling early in life. The appreciation that kindling can alter brain function without any discrete (to date) morphological changes may lead to the development of effective neuroprotective strategies to alter the process, but it is not clear that all kindling-induced changes are detrimental to the brain.

机译：发育过程中短暂性癫痫发作的影响取决于多种因素，例如潜在的脑部病理，特定的发病年龄和发生频率。经常在大鼠中进行研究以确定发育中的大脑癫痫发作的后果。与人类相比，大鼠的青春期前发育和寿命较短，可能表明大鼠的短暂性发作不一定等同于人类的短暂性发作。然而，有大量证据表明，在大鼠中，癫痫发作的后果取决于年龄。未成熟的大脑对形态损伤（尤其是在海马中）和功能变化（如通过电生理学和行为测量）具有相对的抵抗力。发育性点燃可用作研究生命早期短暂发作的模型。点燃会永久性改变大脑，因此成年后再次受刺激的大鼠只需要很少的点燃刺激即可发生完全点燃的癫痫发作，尽管在生命的早期阶段没有明显的海马形态和功能变化。点燃会改变大脑功能而没有任何离散的（迄今为止）形态变化的认识可能会导致开发出有效的神经保护策略来改变这一过程，但是尚不清楚所有点燃引起的变化是否对大脑有害。

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《Progress in brain research》 |2002年第0期|共10页
作者
Velisek L; Moshe SL;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Brain; Seizures; 脑; 发作;

机译：Brain;Seizures;脑;发作;

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专利

1. Effects of brief seizures during development. [J] . Velisek L, Moshe SL Progress in brain research . 2002,第0期

机译：发育过程中短暂发作的影响。
2. Neuroprotective effects of brain-derived neurotrophic factor in seizures during development. [J] . Tandon P, Yang Y, Das K, Neuroscience: An International Journal under the Editorial Direction of IBRO . 1999,第1期

机译：脑源性神经营养因子在发育过程中发作的神经保护作用。
3. Predictors of seizure freedom after surgery for malformations of cortical development. [J] . Chang EF, Wang DD, Barkovich AJ, Annals of neurology . 2011,第1期

机译：皮层发育畸形手术后癫痫发作自由度的预测指标。
4. The effects of different wavelet degrees on epileptic seizure detection from EEG signals [C] . Gunes Ekim, Nuri Ikizler, Ayten Atasoy IEEE International Conference on INnovations in Intelligent SysTems and Applications . 2017

机译：不同小波度对脑电信号癫痫发作检测的影响
5. The Effects of Early-Life Inflammation on Seizure Development and Memory in Neurofibromatosis Type 1 [D] . Faidi, Rania. 2021

机译：早期炎症对神经纤维瘤病癫痫发作和记忆的影响1
6. An unstable ring chromosome in a female infant with hypotonia seizures and retarded development. [O] . L Atkins, R T Sceery, M E Keenan 1966

机译：女婴肌张力低下癫痫发作和发育迟缓的不稳定环染色体。
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Effects of brief seizures during development.

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