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首页> 外文期刊>Progress in brain research >Strategies for regeneration and repair in spinal cord traumatic injury.
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Strategies for regeneration and repair in spinal cord traumatic injury.

机译：脊髓外伤的再生和修复策略。

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摘要

Spinal cord injury is frequently followed by the loss of supraspinal control of sensory, autonomic and motor functions at the sublesional level. In order to enhance recovery in spinal cord-injured patients, we have developed three fundamental strategies in experimental models. These strategies define in turn three chronological levels of postlesional intervention in the spinal cord. Neuroprotection soon after injury using pharmacological tools to reduce the progressive secondary injury processes that follow during the first week after the initial lesion. This strategy was conducted up to clinical trials, showing that a pharmacological therapy can reduce the permanent neurological deficit that usually follows an acute injury of the central nervous system (CNS). A second strategy, which is initiated not long after the lesion, aims at promoting axonal regeneration by acting on the main barrier to regeneration of lesioned axons: the glial scar. Finally a mid-term substitutive strategy is the management of the sublesional spinal cord by sensorimotor stimulation and/or supply of missing key afferents, such as monoaminergic systems. These three strategies are reviewed. Only a combination of these different approaches will be able to provide an optimal basis for potential therapeutic interventions directed to functional recovery after spinal cord injury.
机译：脊髓损伤后常常会在病变旁水平丧失对感觉，自主和运动功能的脊柱上神经控制。为了增强脊髓损伤患者的恢复，我们在实验模型中开发了三种基本策略。这些策略依次定义了脊髓后病变干预的三个时间顺序。损伤后不久使用药理学工具进行神经保护，以减少在最初病变后的第一周进行的进行性继发性损伤过程。该策略一直进行到临床试验，表明药物治疗可以减少通常在中枢神经系统（CNS）急性损伤后出现的永久性神经功能缺损。第二种策略是在病变后不久开始的，旨在通过作用于病变轴突再生的主要障碍：神经胶质瘢痕来促进轴突再生。最后，中期替代策略是通过感觉运动刺激和/或供应缺失的关键传入神经（例如单胺能系统）来管理病变下脊髓。对这三种策略进行了回顾。这些不同方法的组合只能为针对脊髓损伤后功能恢复的潜在治疗干预提供最佳基础。

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