...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Progress in brain research >Brain aging and Alzheimer's disease; use it or lose it.
【24h】

Brain aging and Alzheimer's disease; use it or lose it.

机译：脑衰老和阿尔茨海默氏病;使用它或失去它。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

(1) Alzheimer's disease is a multifactorial disease in which age and APOE-epsilon 4 are important risk factors. (2) The neuropathological hallmarks of AD, i.e. amorphous plaques, neuritic plaques (NPs), pretangles, neurofibrillary tangles (NFT) and cell death are not part of a single pathogenetic cascade but may occur independently. (3) In brain areas where classical AD changes, i.e. NPs and NFTs, are present, such as the CA1 area of the hippocampus, the nucleus basalis of Meynert and the tuberomamillary nucleus, a decreased metabolic rate is found. The decreased metabolic rate appears not to be induced by the presence of pretangles, NFT or NPs. (4) Decreased metabolic rate may precede cognitive impairment and is thus an early occurring hallmark of AD, which, in principle, may be reversible. The observation that the administration of glucose or insulin enhances memory in AD patients also supports the view that AD has a metabolic basis. (5) Moreover, several observations in postmortem brain indicate that activated neurons are better able to withstand aging and AD, a phenomenon paraphrased by us as 'use it or lose it'. (6) It is, therefore, attractive to direct the development of therapeutic strategies towards restimulation of neuronal metabolic rate in order to improve cognition and other symptoms in AD. A number of pharmacological and non-pharmacological studies support the concept that activation of the brain has beneficial effects and may, to a certain degree, restore several aspects of cognition and other central functions. For instance, the circadian system may be restimulated in AD patients by exposing them to more light or transcutaneous nerve stimulation. A procedure has been developed to culture human postmortem brain tissue that allows testing of the efficacy of putative stimulatory compounds such as neurotrophins.
机译：（1）阿尔茨海默氏病是一种多因素疾病，其中年龄和APOE-ε4是重要的危险因素。 （2）AD的神经病理学特征，即无定形斑块，神经炎斑块（NPs），前缠结，神经原纤维缠结（NFT）和细胞死亡不是单个致病级联的一部分，而是可以独立发生。 （3）在存在经典AD改变的脑区域，即NP和NFT，例如海马的CA1区域，Meynert的基础核和结核性乳头状核，发现代谢率降低。降低的代谢速率似乎不是由于存在前缠结，NFT或NPs引起的。 （4）代谢率降低可能在认知障碍之前发生，因此是AD的早期出现标志，原则上是可逆的。葡萄糖或胰岛素的施用增强了AD患者的记忆的观察结果也支持了AD具有代谢基础的观点。 （5）此外，在死后大脑中的一些观察结果表明，活化的神经元更能抵抗衰老和AD，这是我们用“使用或失去它”来形容的现象。 （6）因此，将治疗策略的发展引向神经元代谢率的再刺激以改善AD的认知和其他症状是有吸引力的。许多药理学和非药理学研究支持以下概念：大脑的激活具有有益的作用，并且可以在一定程度上恢复认知和其他中枢功能的多个方面。例如，可以通过使AD患者暴露于更多的光或经皮神经刺激来重新刺激昼夜节律系统。已经开发出一种用于培养人死后脑组织的程序，该程序可以测试假定的刺激性化合物（例如神经营养蛋白）的功效。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号