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首页> 外文期刊>Public health >Thyrotoxicosis outbreak linked to consumption of minced beef and chorizo: Minas, Uruguay, 2003-2004.
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Thyrotoxicosis outbreak linked to consumption of minced beef and chorizo: Minas, Uruguay, 2003-2004.

机译：甲状腺毒症爆发与食用碎牛肉和香肠有关：乌拉圭，米纳斯，2003-2004年。

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OBJECTIVES: Thyrotoxicosis is produced by excessive quantities of thyroid hormone. Its most common causes involve inflammation of the thyroid gland. Much more rarely, thyrotoxicosis is due to exogenous intake of thyroid hormones or iodide compounds. Few outbreaks are documented. In 2003 to early 2004, doctors in Minas, Uruguay noted a sharp increase in the incidence of thyrotoxicosis in a neighbourhood, with multiple cases within families. The objective of this study was to identify the source of the outbreak. STUDY DESIGN: A case-control study was conducted following surveillance and environmental inspection. METHODS: Case patients were symptomatic residents of Minas with documented thyroid-stimulating hormone concentrations <0.1 microUI/ml or <0.49 microUI/ml and elevated free triiodothyronine or free thyroxine. Control subjects were frequency matched with case patients by barrio of residence and age. Case patients, control subjects and persons who prepared and purchased household food were interviewed using a standard questionnaire. Odds ratios adjusted (AOR) for age and gender were calculated by logistic regression in SUDAAN to account for neighbourhood and family clustering. RESULTS: Fifty-nine case patients aged 9-74 years (median 39 years) were identified. Of the 56 interviewed, 52% were women and 71% resided in one barrio. Case patients were more likely than control subjects to eat minced beef at least weekly and purchase it from Butcher A [AOR 6.1; 95% confidence interval (CI) 2.61-14.46], and were more likely to eat chorizo at least weekly and purchase it from Butcher B (AOR 11.6; 95% CI 1.30-102.27). One beef supplier selling meat cuts containing thyroid gland was identified. CONCLUSIONS: The most likely cause of this outbreak of thyrotoxicosis was consumption of minced beef and chorizo contaminated with thyroid gland. Tight regulation and oversight of slaughter, processing, and sales of meat and meat products are imperative for prevention of future outbreaks.
机译：目的：甲状腺毒症是由过量的甲状腺激素产生的。其最常见的原因涉及甲状腺的炎症。甲状腺毒症很少是由于甲状腺激素或碘化物的外源摄入引起的。很少有爆发记录在案。从2003年到2004年初，乌拉圭米纳斯的医生指出，邻里甲状腺毒症的发病率急剧上升，家庭中有很多病例。这项研究的目的是确定爆发源。研究设计：在监测和环境检查之后进行了一项病例对照研究。方法：病例患者是米纳斯病的有症状居民，其甲状腺刺激激素浓度<0.1 microUI / ml或<0.49 microUI / ml，且游离三碘甲状腺素或游离甲状腺素升高。对照受试者通过居住地点和年龄与病例患者频率匹配。使用标准调查表对案例患者，对照组和准备和购买家庭食品的人员进行了采访。通过SUDAAN中的logistic回归计算校正后的年龄和性别几率（AOR），以解决邻里和家庭聚类问题。结果：确定了59例9-74岁（中位39岁）的患者。在接受采访的56位中，有52％是女性，而71％居住在一个地区。病例患者比对照组的患者更有可能至少每周吃碎牛肉并从肉店A购买[AOR 6.1; 95％置信区间（CI）2.61-14.46]，并且更有可能至少每周吃一次香肠并从Butcher B购买（AOR 11.6; 95％CI 1.30-102.27）。确定了一家牛肉供应商，该供应商销售含有甲状腺的肉块。结论：这种甲状腺毒症暴发的最可能原因是食用了碎牛肉和被甲状腺污染的香肠。必须严格监管和监督肉类和肉类产品的屠宰，加工和销售，以防止未来爆发。

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