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首页> 外文期刊>Progress in brain research >Regionalization of the isthmic and cerebellar primordia.
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Regionalization of the isthmic and cerebellar primordia.

机译：峡部和小脑原基的区域化。

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摘要

The complex migrations of neurons born in the dorsal neural tube of the isthmic and rhombomere l (rl) domains complicate the delineation of the cerebellar primordium. We show that Purkinje cells (P) are likely generated over a wide territory before gathering in the future cerebellar primordium under the developing external granular layer. Later expansion of the cerebellum over a restricted ependymal domain could rely on mutual interations between P cells and granule cell progenitors (GCP). P are attracted by GCP and in turn stimulate their proliferation, increasing the surface of the developing cortex. At later stages, regionalization of the developing and adult cerebellar cortex can be detected through regional variations in the distribution of several P cell markers. Whether and how the developmental and adult P subtypes are related is still unknown and it is unclear if they delineate the same sets of cerebellar subdivisions. We provide evidence that the early P regionalization is involved in intrinsic patterning of the cerebellar primordium, in particular it relate to the organization of the corticonuclear connection. We propose that the early P regionalization provides a scaffold to the mature P regionalization but that the development of functional afferent connections induces a period of P plasticity during which the early regional identity of P could be remodeled.
机译：局灶性和菱形l（rl）域的背神经管中出生的神经元的复杂迁移使小脑原基的描绘变得复杂。我们显示浦肯野细胞（P）可能会在广阔的领土上生成，然后聚集在发育中的外部颗粒层下的未来小脑原基中。小脑在受限的室间隔区域上的扩展可能依赖于P细胞和颗粒细胞祖细胞（GCP）之间的相互关系。 P被GCP吸引，进而刺激它们的增殖，增加了发育中的皮层的表面。在以后的阶段，可以通过几种P细胞标记物分布的区域变化来检测发育中的和成年的小脑皮质的区域化。发育和成人P亚型是否相关以及如何相关仍是未知的，还不清楚它们是否描绘了相同的小脑细分。我们提供的证据表明，早期的P区域化参与了小脑原基的固有模式，特别是它与皮质核连接的组织有关。我们建议，早期的P区域化为成熟的P区域化提供了支撑，但是功能传入连接的发展引发了P的可塑性时期，在此期间P的早期区域特性可以被重塑。

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