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首页> 外文期刊>Progress in brain research >Nerve growth factor, human skin ulcers and vascularization. Our experience.
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Nerve growth factor, human skin ulcers and vascularization. Our experience.

机译：神经生长因子，人类皮肤溃疡和血管形成。我们的经验。

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摘要

Cutaneous wound is known to elicit a series of typical cellular responses that include clotting, inflammatory infiltration, reepithelialization, the formation of granulation tissue, including new blood vessel, followed by tissue remodeling and wound contraction. The regulatory molecules implicated in these events are not well known. Neurotrophins and their receptors are trophic factors that are known to play important roles in cutaneous tissues, nerve development and reconstruction after injury. Among the neurotrophins, the nerve growth factor (NGF) was one of the earliest used for clinical studies. NGF has been tested for potential therapeutic application in neuropathies of the central and peripheral nervous system and more recently in human corneal and cutaneous ulcers. Here, I present and discuss data obtained in the last few years on the healing action of NGF in human and domestic animal skin ulcers.
机译：已知皮肤伤口会引起一系列典型的细胞反应，包括凝血，炎性浸润，再上皮化，肉芽组织（包括新血管）的形成，随后的组织重塑和伤口收缩。与这些事件有关的调节分子不是众所周知的。神经营养蛋白及其受体是营养因子，已知在损伤后的皮肤组织，神经发育和重建中起重要作用。在神经营养蛋白中，神经生长因子（NGF）是最早用于临床研究的物质之一。已对NGF在中枢神经系统和周围神经系统的神经病以及最近在人角膜和皮肤溃疡中的潜在治疗应用进行了测试。在这里，我介绍并讨论了最近几年获得的有关NGF在人类和家畜皮肤溃疡中的愈合作用的数据。

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