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首页> 外文期刊>Progress in brain research >The nicotinic acetylcholine receptor subtypes and their function in the hippocampus and cerebral cortex.
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The nicotinic acetylcholine receptor subtypes and their function in the hippocampus and cerebral cortex.

机译：烟碱型乙酰胆碱受体亚型及其在海马和大脑皮层中的功能。

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Nicotinic acetylcholine receptors (nAChRs) are widely distributed in the central nervous system and have been implicated in multiple behavioral paradigms and pathological conditions. Nicotinic therapeutic interventions require an extensive characterization of native nAChRs including mapping of their distribution and function in different brain regions. Here, we describe the roles played by different nAChRs in affecting neuronal activity in the hippocampus and cerebral cortex. At least three distinct functional nAChR subtypes (alpha 7, alpha 4 beta 2, alpha 3 beta 4) can be detected in the hippocampal region, and in many instances a single neuron type is found to be influenced by all three nAChRs. Further, it became clear that GABAergic and glutamatergic inputs to the hippocampal interneurons are modulated via different subtypes of nAChRs. In the cerebral cortex, GABAergic inhibition to the layer V pyramidal neurons is enhanced predominantly via activation of alpha 4 beta 2 nAChR and to a minor extent via activation of alpha 7 nAChR. Such diversity offers pathways by which nicotinic drugs affect brain function.
机译：烟碱型乙酰胆碱受体（nAChRs）广泛分布于中枢神经系统，并涉及多种行为范例和病理状况。烟碱治疗干预措施需要对天然nAChRs进行广泛的表征，包括对其在不同大脑区域的分布和功能进行定位。在这里，我们描述了不同的nAChRs在影响海马和大脑皮层神经元活动中所起的作用。在海马区可以检测到至少三种不同的功能性nAChR亚型（α7，α4β2，α3β4），并且在许多情况下，发现单个神经元类型受所有三种nAChR的影响。此外，已经清楚的是，通过nAChR的不同亚型调节对海马中间神经元的GABA能和谷氨酸能输入。在大脑皮层中，主要通过激活α4 beta 2 nAChR增强对V层锥体神经元的GABA能抑制，并在较小程度上通过激活α7 nAChR增强。这种多样性提供了烟碱类药物影响脑功能的途径。

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