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Neural stem and progenitor cells: choosing the right Shc.

机译:神经干细胞和祖细胞:选择合适的Shc。

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摘要

Neural stem cell (NSCs) are self-renewing, multipotent cells able to generate neurons, astrocytes and oligodendrocytes. Since their identification, these properties have made NSCs an attractive subject for therapeutic applications to the damaged brain. In this context, understanding the mechanisms and the molecules regulating their biological properties is important and it is focused to gain control over their proliferative and differentiative potential. Here we will discuss values and unsolved aspects of the system and the employment of potentially key molecular targets for proper control of NSCs fate.
机译:神经干细胞(NSC)是自我更新的多能细胞,能够产生神经元,星形胶质细胞和少突胶质细胞。自鉴定以来,这些特性使NSC成为治疗受损大脑的诱人对象。在这种情况下,了解调节其生物学特性的机制和分子很重要,并且重点是控制其增殖和分化潜能。在这里,我们将讨论系统的价值和尚未解决的方面,以及为适当控制NSC命运而使用潜在的关键分子靶标的方法。

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