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首页> 外文期刊>Progress in brain research >Dynamics of thalamo-cortical network oscillations and human perception.
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Dynamics of thalamo-cortical network oscillations and human perception.

机译:丘脑-皮质网络振动和人类感知的动态。

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There is increasing evidence that human cognitive functions can be addressed from a robust neuroscience perspective. In particular, the distributed coherent electrical properties of central neuronal ensembles are considered to be a promising avenue of inquiry concerning global brain functions. The intrinsic oscillatory properties of neurons (Llinas, R. (1988) The intrinsic electrophysiological properties of mammalian neurons: Insights into central nervous system function. Science, 242: 1654-1664), supported by a large variety of voltage-gated ionic conductances are recognized to be the central elements in the generation of the temporal binding required for cognition. Research in neuroscience further indicates that oscillatory activity in the gamma band (25-50 Hz) can be correlated with both sensory acquisition and pre-motor planning, which are non-continuous functions in the time domain. From this perspective, gamma-band activity is viewed as serving a broad temporal binding function, where single-celloscillators and the conduction time of the intervening pathways support large multicellular thalamo-cortical resonance that is closely linked with cognition and subjective experience. Our working hypothesis is that although dedicated units achieve sensory processing, the cognitive binding process is a common mechanism across modalities. Moreover, it is proposed that such time-dependent binding when altered, will result in modifications of the sensory motor integration that will affect and impair cognition and conscious perception.
机译:越来越多的证据表明,可以从强大的神经科学角度解决人类的认知功能。尤其是,中枢神经元集成体的分布式相干电特性被认为是有关整体脑功能的有前途的研究途径。神经元的固有振荡特性(Llinas,R.(1988)哺乳动物神经元的固有电生理特性:对中枢神经系统功能的洞察。Science,242:1654-1664)受到多种电压门控离子电导的支持被认为是认知所需的时间约束的产生的核心要素。神经科学方面的研究进一步表明,γ波段(25-50 Hz)中的振荡活动可以与感觉获取和运动前计划相关联,这在时域中是不连续的功能。从这个角度来看,γ-带活动被认为具有广泛的时间绑定功能,其中单细胞振荡器和中间通路的传导时间支持与认知和主观经验密切相关的大型多细胞丘脑皮质共振。我们的工作假设是,尽管专用单元实现了感觉处理,但认知绑定过程是跨模式的常见机制。此外,提出这样的时间依赖性结合改变时,将导致感觉运动整合的改变,这将影响并损害认知和意识。

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