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首页> 外文期刊>Progress in brain research >Axonal and synaptic remodeling in the mature cerebellar cortex.
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Axonal and synaptic remodeling in the mature cerebellar cortex.

机译：成熟的小脑皮质的轴突和突触重塑。

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By blocking electrical activity in the cerebellar cortex the Purkinje cell dendrites become a uniform territory with a high density of spines all bearing the glutamate receptor delta2 subunit (GluRdelta2) and being mainly innervated by parallel fibers. Such a subunit, which is constitutively targeted specifically to the parallel fiber synapses, appears in the spines contacted by the climbing fibers before they disconnect from the target. A similar pattern of hyperspiny transformation and innervation occurs a few days after a subtotal lesion of the inferior olive, the source of climbing fibers. During the climbing fiber reinnervation process which follows the removal of the electrical block or by collateral sprouting of surviving inferior olive neurons, the new active climbing fibers establish synaptic contacts with proximal dendritic spines that bear GluRdelta2s. After, they repress these subunits and displace the parallel fibers to the distal dendritic territory. These findings suggest the following operational principle in the axonal competition for a common target. The Purkinje cells have an intrinsic phenotypic profile which is compatible with the parallel fiber innervation, this mode being operational in targets innervated by a single neuronal population, like the neuromuscular system. An additional input, the climbing fibers, in order to achieve its own territory on the proximal dendrite needs the ability to displace the competitor. Such an inhibition is activity-dependent and the activity needs to be present in order to allow the climbing fiber to maintain its territory, even when the developmental period is over.
机译：通过阻断小脑皮层中的电活动，浦肯野细胞树突成为具有高密度刺的均一区域，所有刺均带有谷氨酸受体δ2亚基（GluRdelta2），并且主要被平行纤维支配。组成性地专门针对平行纤维突触的这种亚基出现在攀登纤维与靶标断开连接之前与攀登纤维接触的刺中。下橄榄的小计部分病变（攀爬纤维的来源）几天后，发生了类似的多刺转化和神经支配模式。在去除电传导阻滞或通过存活的下橄榄神经元的侧枝萌发之后的攀爬纤维再支配过程中，新的活性攀爬纤维与带有GluRdelta2s的近端树突棘建立突触接触。之后，他们压制这些亚基，并将平行纤维移至远端树突区域。这些发现暗示了在针对共同目标的轴突竞争中的以下操作原理。浦肯野细胞具有与并行纤维神经支配兼容的内在表型特征，这种模式可在单个神经元种群（如神经肌肉系统）支配的靶标中起作用。为了在近端枝晶上获得其自身的区域，需要额外的输入，即攀爬纤维，以使竞争者移位。这种抑制是依赖于活性的，并且即使在发育期结束时，也需要存在活性以使攀登纤维保持其领土。

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