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首页> 外文期刊>Progress in brain research >Co-localization of GABA with other neuroactive substances in the basal ganglia.
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Co-localization of GABA with other neuroactive substances in the basal ganglia.

机译:GABA与其他神经活性物质在基底神经节中共定位。

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摘要

The dorsal striatum (caudate putamen) contains two types of GABAergic medium spiny neurons (MSNs) that are distinguished by the expression of either the opioid peptide, enkephalin, or the opioid peptide, dynorphin, as well as the tachykinin substance P. Pharmacological studies suggest that these peptides modulate local neurotransmission in the striatum in response to direct and indirect dopamine agonists. In contrast, GABA appears to have minimal impact within the striatum under these conditions. The actions of the peptide cocktail are dependent on the cellular distribution of their receptors in the striatal network. The net result of their actions is a homeostatic response that regulates striatal output and balances dopamine and glutamate receptor stimulation.
机译:背侧纹状体(尾状壳核)包含两种类型的GABA能中突棘神经元(MSN),其特征在于阿片样肽脑啡肽或阿片肽强啡肽的表达以及速激肽物质P。药理学研究表明这些肽响应直接和间接的多巴胺激动剂而调节纹状体中的局部神经传递。相反,在这些条件下,GABA在纹状体内的影响似乎最小。肽混合物的作用取决于其受体在纹状体网络中的细胞分布。它们作用的最终结果是稳态反应,该反应调节纹状体输出并平衡多巴胺和谷氨酸受体的刺激。

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