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首页> 外文期刊>Progress in brain research >Development of striatal fast-spiking GABAergic interneurons.
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Development of striatal fast-spiking GABAergic interneurons.

机译：纹状体快速加标的GABA能中间神经元的发展。

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Fast-spiking GABAergic interneurons represent a very small portion of striatal neurons, yet they play a critical role in modulating cortical input and mediating inhibition of striatal medium-sized spiny projection neurons. Considering their pivotal role in the adult striatum, it is of importance to determine when during development these neurons acquire their characteristic properties and function. In this review we describe recent work from our laboratories indicating that fast-spiking GABAergic interneurons are under stronger cortical control than efferent neurons at postnatal day 12 but mature considerably between postnatal days 12-19 in the rat striatum. During this time period, their molecular development is under the control of GABAergic and cholinergic mechanisms. Thus, fast-spiking interneurons are poised to influence striatal function and perhaps development during the postnatal period in rats, and their properties could be influenced by commonly used pharmacological agents during a protracteddevelopmental window. These findings point to the need for future research to better understand the functional maturation of this critical population of striatal GABAergic neurons, and the consequences of abnormal maturation of these cells.
机译：快速加标的GABA能神经元仅占纹状体神经元的一小部分，但它们在调节皮质输入和介导对纹状体中型棘突投射神经元的抑制中起关键作用。考虑到它们在成年纹状体中的关键作用，重要的是确定这些神经元在发育过程中何时获得其特征和功能。在这篇综述中，我们描述了我们实验室的最新工作，这些研究表明，快出生的GABA能神经元在出生后第12天比传出的神经元受到更强的皮质控制，但在大鼠纹状体出生后第12-19天之间已经相当成熟。在这段时间内，它们的分子发育受GABA能和胆碱能机制的控制。因此，快速掺入的中间神经元可能会影响大鼠的纹状体功能，甚至可能影响其出生后的发育，并且它们的特性可能会在长期的发育期受到常用药理学的影响。这些发现表明，有必要进行进一步的研究，以更好地了解这一重要的纹状体GABA能神经元的功能成熟以及这些细胞异常成熟的后果。

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